直肠癌旁移行粘膜P53的表达及其意义  

Expression of P53 Protein in Transitional Mucosa Adjacent to Rectal Carcinoma and Its Clinical Significance

作　　者：冯茂辉[1] 杨国梁 王米娜[1] 王善福[1] 程伏林 黄金球 

机构地区：[1]黄石市一医院

出　　处：《湖北医科大学学报》1998年第2期147-149,152,共4页

摘　　要：采用组织化学和免疫组织化学方法观察３４例直肠癌远端癌旁粘膜中Ｐ５３蛋白表达及其与粘蛋白改变的关系。结果提示２９．４％（１０／３４）直肠癌旁移行粘膜腺体杯状细胞胞浆内存在Ｐ５３表达，其范围不超出远端４ｃｍ肠管，Ｐ５３阳性表达的粘膜均为移行改变粘膜，正常粘膜无Ｐ５３蛋白表达；Ｐ５３在癌组织与癌旁移行粘膜中表达无相关性（Ｐ＞０．０５）。认为直肠癌旁移行粘膜中存在Ｐ５３的失活，系不稳定的癌前期病变，直肠癌远端粘膜粘蛋白异常改变及分子遗传学异常范围在４ｃｍ以内。Thirty four cases were subjected to mucin histochemical and immunohistochemical study to observe the expression of P53 protein in distal mucosa adjecent to rectal carcinoma and its relationship to the mucin change. The results showed that expression of P53 protein was found in 29.4% (10/34) of distal transitional mucosa in the cytoplasm of goblet cells, and its positive staining was with 4 cm distance from carcinoma margin. All P53 positive mucosa was transitional mucosa. There was no relationship between the expression of P53 protein in carcinoma and that in transitional mucosa ( P >0.05). These findings indicate that there is aberrant alteration of P53 gene in transitional mucosa adjacent to colorect carcinoma, providing further evidence that transitional mucosa is an unstable premalignant change. The aberrant mucin change and genetic alteration in distal mucosa of rectal cancer is with 4 cm.

关 键 词：直肠肿瘤 肠粘膜 P53基因 免疫组织化学 

分 类 号：R735.370.2[医药卫生—肿瘤]