一氧化氮及相关因素在脑梗塞病人急性期中的作用机制  

The mechanism of action on nitric oxide and correlative factors in the patients with cerebral infarction in acute stage

作　　者：吕晓红[1,2] 李恩民[1,2] 饶明俐[1,2] 张淑琴[1,2] 林卫红[1,2] 

机构地区：[1]白求恩医大一院神经内科 [2]白求恩医大应用基础研究所

出　　处：《中风与神经疾病杂志》1998年第2期73-75,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的从临床角度探讨一氧化氮在脑梗塞病人急性期中的作用机制。方法利用分光光度法及荧光分光光度法分别测定了脑梗塞病人急性期及恢复期血浆中的ＮＯ、ＶｉｔＥ、ＶｉｔＡ、ＭＤＡ及ＷＳＦＳ的含量变化。结果脑梗塞病人急性期ＮＯ及ＭＤＡ含量明显升高，ＶｉｔＥ、ＶｉｔＡ则明显下降，ＮＯ与ＶｉｔＥ两者呈显著负相关；而ＷＳＦＳ的含量则改变不明显。结论ＮＯ在脑梗塞病人中具有双向作用；Objective Studies of the mechanism of action on nitric oxide and correlative factors in the patients with cerebral infarction in acute stage.Methods The content of nitric oxide(NO),Vit E,Vit A,molondialehyde(MDA) and water soluble fluorescent substance(WSFS) in the plasma of cerebral infarct patients was mensurated with spectrophotometry and fluorescent spectrophotometry.Results No contend in the plasma of cerebral infarct patients in acute stage was significantly higher than those in convalescent stage and/on control,the content of Vit E and Vit A come down,MDA and WSFS were not significantly change.Conclusions No has the two way action in the acute stage of cerebral infarct patients.Its base release dose has physiologic function,the excessive NO has neurotoxicity.

关 键 词：一氧化氮 脑梗塞 作用机制 相关因素 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]