三阴性乳腺癌的临床病理特点及预后因素分析  

The Clinicopathologic Characteristics and Prognostic Factors Analysis of the ER,PR,HER2 Negative Breast Cancer

作　　者：陈晓耕[1] 林志武[1] 柳燕[1] 林镇和[1] 

机构地区：[1]福建医科大学省立临床学院肿瘤外科,福州350001

出　　处：《福建医科大学学报》2009年第2期172-174,共3页Journal of Fujian Medical University

摘　　要：目的探讨三阴性(TN)乳腺癌的临床病理特点及影响预后的因素。方法回顾性分析515例乳腺癌患者,根据雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)的表达,将其分为3组:三阴组(ER阴性、PR阴性、HER2阴性)、HR组(ER阳性或PR阳性、HER2阴性或阳性)、HER2组(ER阴性、PR阴性、HER2阳性)。分析各组的临床病理特点、复发及生存情况。结果三阴组与HR组、HER2组相比,患者年龄小、肿瘤较大、浸润性导管癌多见,淋巴结转移率与肿瘤大小有统计学意义;三阴组复发时间较早(2.32年),复发率(23.91%)和死亡率(22.72%)均较高;患者复发风险呈先升后降的趋势:术后1～4年达到顶峰,之后下降。结论三阴性乳腺癌患者诊断时年龄小、原发肿瘤大、淋巴结转移率高、术后5年内复发和死亡风险高。Objective To analyze the clinicopathological characteristics and prognostic factors in ER,PR,HER-2 negative breast cancer. Methods The data of 515 were retrospectively analyzed. According to the expression of ER,PR,HER2, 515 patients were put into 3 groups. HR （ER or PR＋） ,triple negative （all ER, PR, HER2 ＋ ）, and HER2 （ER -, PR-, HER2 ＋ ）. The clinicopathological features, recurrence and survival of each group were analyzed. Results The mean age for the triple negative group was （48.53±9.09） ; The mean tumor size was （3.52 ± 1.36）cm. Invasive ductal carcinoma in this group were the highest proportion; and the lymph node metastasis rate and tumor size were statistically significant. The triple negative group relapsed earlier （2. 32 years）, relapse rate （23. 91%） and mortality （22.72%） are higher; The trend of relapse risk about the triple negative group was first and then decreased： Peaked within 1～3 years, followed by decline. Conclusion Compared with non TN, the breast cancer patiens with triple-negativeis characterized by the following： younger,larger primary tumor, higher rate of lymphnode metastasis, the higher risk of recurrence and death within 5 years.

关 键 词：乳腺肿瘤 受体.孕酮 受体 雌激素 受体 cerbB-2 淋巴转移 预后 

分 类 号：R737.902.2[医药卫生—肿瘤] R195.1[医药卫生—临床医学]