原发性肾透明细胞癌中转移相关基因CD99、FKBP5和FLJ13576的表达  

Expression of metastasis-associated molecules CD99,FKBP5,FLJ13576 in primary clear cell renal cell carcinoma

作　　者：曹廷虎[1,2] 侯建国[1] 常文军[3] 翟羽佳[3] 林丽萍[3] 顾春英[3] 谭晓洁[3] 曹广文[3] 

机构地区：[1]第二军医大学长海医院泌尿外科,上海200433 [2]上海市宝山中心医院泌尿外科,上海201900 [3]第二军医大学基础部流行病学教研室,上海200433

出　　处：《第二军医大学学报》2009年第4期360-363,共4页Academic Journal of Second Military Medical University

基　　金：上海市教委科技创新重点项目(08zz39)~~

摘　　要：目的:探讨肿瘤转移相关分子CD99、FKBP5、FLJ13576在原发性肾透明细胞癌中的表达。方法:应用半定量RT-PCR技术研究肿瘤转移相关分子CD99、FKBP5、FLJ13576在肾透明细胞癌组织和癌旁组织中的差异性表达。结果:CD99、FKBP5、FLJ13576在原发性肾透明细胞癌组织中的表达率分别为72%、60%和48%,而对应癌旁组织中的表达率分别为28%、24%和16%,表达水平也明显不同。肾透明细胞癌组织中CD99、FKBP5和FLJ13576 3种基因的表达水平均显著高于癌周组织(P<0.05)。结论:肿瘤转移相关分子CD99、FKBP5、FLJ13576在肾透明细胞癌原发组织中的表达明显上调,可能与肾细胞癌发生、发展密切相关,有望成为检测肾细胞癌的新的生物学标志。Objective： To evaluate the expression of metastasis associated molecules CD99, FKBP5 and FLJ13576 in primary clear cell renal cell carcinoma （ccRCC）. Methods： Semi-quantitative reverse transcription polymerase chain reaction （RT-PCR） was used to examine the differential expression of CD99, FKBP5, and FLJ13576 in the primary ccRCC tissues and the corresponding adjacent normal renal tissues. Results： The positive rates of CD99, FKBPS, and FLJ13576 in the primary ccRCC tissues were 72%, 60% and 48%, respectively, which were significantly higher than those in the adjacent normal renal tissues（28%, 24%, and 16%, P〈0.05）. Conclusion： Cancer metastasis-associated molecules CD99, FKBP5 and FLJ13576 are highly expressed in the primary ccRCC tissues, which might be associated with the development and progression of renal cancer. CD99, FKBP5 and FLJ13576 may serve as potential markers for detection of ccRCC.

关 键 词：肾肿瘤 CD99 FKBP5 FLJ13576 基因表达 透明细胞癌 

分 类 号：R737.11[医药卫生—肿瘤]