电压门控性钾通道与三叉神经痛  

Voltage-gated potassium channels and trigeminal neuralgia

作　　者：李娜[1] 马蓓[2] 邓小明[1] 

机构地区：[1]第二军医大学长海医院麻醉科,上海200433 [2]第二军医大学基础部生理学教研室,上海200433

出　　处：《第二军医大学学报》2009年第4期432-436,共5页Academic Journal of Second Military Medical University

基　　金：上海市科学技术委员会基金(08JC1405400)~~

摘　　要：电压门控性钾通道维持神经元静息膜电位,参与细胞兴奋性的改变。在三叉神经痛发病过程中,三叉神经节神经元作为初级感觉神经元,在痛觉的传导和传递过程中起重要作用。电压门控性钾通道的多种类型在三叉神经节神经元中均有表达,激活时产生不同类型的钾电流。电压门控性钾通道功能的改变,及其与多种神经递质、炎性介质和受体间的相互作用,在三叉神经痛的发病过程中起到了重要作用。Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons. Trigeminal ganglion as a primary sensory neuron plays an important role in the pain transduction and transmission of trigeminal neuralgia. Trigeminal ganglion neurons express many subtypes of voltage gated potassium channels and they can evoke different type of K＋ current when activated. The alteration of voltage-gated potassium channels and their interaction with neurotransmitters, inflammatory eytokines and receptors play important roles in the development of trigeminal neuralgia.

关 键 词：电压门控钾通道 三叉神经痛 三叉神经节 背根神经节 受体 

分 类 号：R745.11[医药卫生—神经病学与精神病学]