产后康口服液质量标准研究  

Study on the Quality Standard of Chanhoukang Oral Liquid

作　　者：储秋萍[1] 朱子寒[1] 

机构地区：[1]南京医科大学第一附属医院,南京210029

出　　处：《中国药事》2009年第4期362-364,共3页Chinese Pharmaceutical Affairs

摘　　要：目的建立产后康口服液的质量控制标准。方法采用薄层色谱法对制剂中的当归、川芎、益母草进行定性鉴别;采用高效液相色谱法对阿魏酸进行含量测定。色谱柱为Hypersil ODS柱;流动相:甲醇-5%醋酸(25∶75),流速:1.0 mL.min-1;检测波长:320nm。结果阿魏酸线性范围在0.167～1.668μg(r=0.9996);平均回收率为98.55%,RSD=1.69%(n=9)。结论方法简便、准确、重复性好,可用于产后康口服液质量控制。Objective To establish a quality standard for Chanhoukang Oral Liquid. Methods TLC was used to identify Radix Angelicae Sinensis, Rhizoma Chuanxiong and Herba Leonari. HPLC method for the determination of ferulic acid in Chanhoukang Oral Liquid was established. The separation was performed on Hypersil ODS column, using with methanol-5%HAc （25： 75） as mobile phase, the flow rate was 1.0 mL·min^-1 , the detection wave length was 320nm. Results The calibration curve was linear in the range of 0. 167-1. 668μg （r=0. 9996）. The average recovery was 98. 55%, RSD=1. 69 % （n=9）. Conclusions The method is simple and accurate and highly reproducible. It could be used for the quality control of Chanhoukang Oral Liquid.

关 键 词：产后康口服液 阿魏酸 质量标准 

分 类 号：R284.2[医药卫生—中药学]