乳腺浸润性导管癌：超声征象与ER、C-erbB-2表达的关系  

Infiltrating ductal cancer of breast:correlation between ultrasonographic features and ER,C-erbB-2 expression level

作　　者：庞彩霞 李智贤 丁雪明 张莉 韦康来[2] 黄克强[2] 

机构地区：[1]不详 [2]广西医科大学第一附属医院病理科,广西南宁530021

出　　处：《中国医学影像技术》2009年第3期449-452,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家“十一五”科技支撑计划项目基金(2007BAI07A17-11)

摘　　要：目的探讨乳腺浸润性导管癌(IDC)超声征象和雌激素受体(ER)、人表皮生长因子受体-2(C-erbB-2)之间的关系。方法将207例经手术病理证实的IDC的主要超声表现与术后标本免疫组织化学染色评价的ER、C-erbB-2表达情况进行对照分析。结果①在207例IDC中,ER阳性率为57.97%(120/207),超声显示肿块有边缘毛刺征、后方声衰减者肿块ER阳性率高于不具有上述征象者(P<0.05);②C-erbB-2过表达率为29.95%(62/207),有微钙化征象者肿块C-erbB-2过表达率高于无微钙化征象者(P<0.05)。结论IDC的主要超声征象中的边缘毛刺征、后方声衰减可在一定程度上预测肿块ER的表达水平;微钙化征象可在一定程度上预测肿块C-erbB-2的过表达水平。Objective To probe the relationship between the appearance on ultrasonic sign and estrogen receptor （ER）, C- erbB-2 in infiltrating ductal carcinoma of breast （IDC）, and to evaluate the possibility of predicting the expression of ER and C-erbB-2 in IDC preoperation by means of ultrasonography. Methods A total of 207 patients with IDC confirmed pathologically were involved in this study. ER and C-erbB-2 expression of the mastectomy specimens was determined with immunohistochemical staining technique. The correlation between the ultrasonographic features and ER, C-erbB-2 positive expression was analyzed. Results ①Of 207 cases, the ER positive rate was 57.97% （120/207）. ER positive rate in lesions with spicule sign or posterior shadowing attenuation of the ultrasonography was higher than that in lesions without the certain ultra sonographic features （P〈0.05）. ②Of 207 cases, the C-erbB-2 over expressive rate was 29.95%（62/207）, and the C-erbB-2 over expressive rate in lesions with the microcalcifications of the ultrasonography was higher than that in lesions without microcalcifications （P〈0.05）. Conclusion The spicule sign and posterior shadowing attenuation of the ultrasonography have certain correlation with ER expression in patients with IDC, while the microcalcifications have certain correlation with C-erbB-2 over expression .

关 键 词：超声检查 乳腺浸润性导管癌 雌激素受体 人表皮生长因子受体-2 

分 类 号：R737.9[医药卫生—肿瘤] R512.62[医药卫生—临床医学]