超声观察长期服用抗精神病药物患者肝胆改变  

Ultrasound observation of liver and gallbladder changes in patients with long term application of antipsychotics

作　　者：蚁丽芬[1] 李雪影[2] 王汉婵[1] 蚁舒[1] 朱少毅[1] 

机构地区：[1]汕头大学精神卫生中心B超室,广东汕头515063 [2]汕头大学医学院第一附属医院超声科,广东汕头515041

出　　处：《中国医学影像技术》2009年第4期653-655,共3页Chinese Journal of Medical Imaging Technology

基　　金：广东省医学科学技术研究基金(A2006464)

摘　　要：目的观察长期服用抗精神病药物治疗精神分裂症患者的肝胆改变。方法对2255例精神分裂症患者行常规肝胆B超检查,抽取服用抗精神病药物5年以上患者250例(研究组),服药5年以下患者250例(对照组1),并对同期未患精神疾病的常规体检者250名(对照组2)行B超检查。结果研究组与两个对照组间的肝胆B超异常阳性率比较差异均有显著统计学意义(P<0.01),而两对照组间差异无统计学意义(P>0.05)。脂肪肝在各组中的发生率最高。研究组中不同病程、年龄肝胆B超异常阳性率差异有统计学意义(P<0.05)。性别和精神分裂症的类型不同肝胆B超异常阳性率差异无统计学意义(P>0.05)。结论服用抗精神病药物5年以上者肝胆异常、特别是脂肪肝发生率显著增高。Objective To observe the changes of liver and gallbladder in patients with long term antipsychotics application. Methods A total of 2255 schizophrenic patients underwent type-B ultrasonography, 250 schizophrenic patients who used antipsychotics for more than 5 years were chosen as study group, and 250 schizophrenic patients who used antipsychotics for less than 5 years as control group 1, meanwhile 250 healthy people who did regular check-ups as control group 2. Results The difference of the unnatural positive rate between the study group and two control groups were statistically significant （P〈0.01）, there was no statistical difference between the two control groups （P〉0.05）. The incidence of fatty liver was the highest among the three groups. The statistical differences of unnatural positive rate of the study group existed in patient＇s age and course of the disease （P〈0.05）, but there were no statistical differences of gender and the type of the schizophrenia （P〉0.05）. Conclusion The imaging changes of type-B ultrasound can clearly indicate the lesions of liver and gallbladder.

关 键 词：精神分裂症 抗精神病药物 肝脏 胆囊 超声检查 

分 类 号：R575[医药卫生—消化系统] R445.1[医药卫生—内科学]