Reactive oxygen species: A double-edged sword in oncogenesis  

作　　者：Jin-Shui Pan Mei-Zhu Hong Jian-Lin Ren 

机构地区：[1]Division of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China [2]Gastroenterology Institute of Xiamen University, Xiamen 361004, Fujian Province, China [3]Gastroenterology Center of Xiamen, Xiamen 361004, Fujian Province, China [4]Division of Infectious Diseases, the 174th Hospital ofPLA, Xiamen 361003, Fujian Province, China

出　　处：《World Journal of Gastroenterology》2009年第14期1702-1707,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China, No. 30750013 ;Key Science Research Project Natural Science Foundation of Xiamen, No. WKZ0501

摘　　要：Reactive oxygen species (ROS) are molecules or ions formed by the incomplete one-electron reduction of oxygen. Ofinterest, it seems that ROS manifest dual roles, cancer promoting or cancer suppressing, in tumorigenesis. ROS participate simultaneously in two signaling pathways that have inverse functions in tumorigenesis, Ras-Raf-MEK1/2-ERK1/2 signaling and the p38 mitogen-activated protein kinases (MAPK) pathway. It is well known that Ras-Raf-MEK1/2-ERK1/2 signaling is related to oncogenesis, while the p38 MAPK pathway contributes to cancer suppression, which involves oncogene-induced senescence, inflammationinduced cellular senescence, replicative senescence, contact inhibition and DNA-damage responses. Thus, ROS may not be an absolute carcinogenic factor or cancer suppressor. The purpose of the present review is to discuss the dual roles of ROS in the pathogenesis of cancer, and the signaling pathway mediating their role in tumorigenesis.Reactive oxygen species （ROS） are molecules or ions formed by the incomplete one-electron reduction of oxygen. Of interest, it seems that ROS manifest dual roles, cancer promoting or cancer suppressing, in tumorigenesis. ROS participate simultaneously in two signaling pathways that have inverse functions in tumorigenesis, Ras-Raf-MEK1/2-ERK1/2 signaling and the p38 mitogen-activated protein kinases （MAPK） pathway. It is well known that Ras-Raf-MEK1/2-ERK1/2 signaling is related to oncogenesis, while the p38 MAPK pathway contributes to cancer suppression, which involves oncogene-induced senescence, inflammation- induced cellular senescence, replicative senescence, contact inhibition and DNA-damage responses. Thus, ROS may not be an absolute carcinogenic factor or cancer suppressor. The purpose of the present review is to discuss the dual roles of ROS in the pathogenesis of cancer, and the signaling pathway mediating their role in tumorigenesis.

关 键 词：p38 mitogen-activated protein kinases Reactive oxygen species Signal transduction TUMORIGENESIS 

分 类 号：R339.38[医药卫生—人体生理学] R698.2[医药卫生—基础医学]