巨块型子宫颈癌术前超选择动脉内栓塞化疗26例  

Value of superselective intraarterial infusion chemotherapy and embolization in advanced cervical carcinoma patients before surgery

作　　者：陈亚君[1] 张水蓉[1] 徐炎华[1] 

机构地区：[1]华中科技大学同济医学院附属荆州医院肿瘤科,434020

出　　处：《肿瘤研究与临床》2009年第4期259-260,共2页Cancer Research and Clinic

摘　　要：目的探讨超选择动脉内灌注化疗加栓塞术前治疗晚期子宫颈癌的临床疗效。方法2004年1月至2008年3月间住院未经治疗的ⅡA～Ⅳ期子宫颈癌患者共26例，术前在数字减影血管造影术监视下，采用Seldinger技术行双侧髂内动脉插管灌注化疗药，卡铂80mg，长春新碱2mg，丝裂霉素16mg，明胶海绵颗粒栓塞肿瘤供血明显的分支。妇科检查结合超声和CT测量化疗前后肿瘤大小，计算肿瘤消退百分比。1个月后行根治性子宫切除术。结果栓塞化疗总有效率为92．3％。结论术前化疗可缩小肿瘤病灶，减少淋巴结转移和亚临床播散，增加了根治性子宫切除的机会，有望提高晚期子宫颈癌患者的生活质量和生存率。Objective To investigate the clinical effect of superselective arterial infusion chemotherapy（SACT） and embolization in advanced cervical carcinoma patients before surgery. Methods 26 previously untreated patients with stage ⅡA～Ⅳ cervical carcinoma admitted from January 2004 to March 2008 were enrolled into the study, patients underwent SACT of the internal iliac artery（dose of the drug： CBP 80 mg, VCR 2 mg, MMC 16 mg ） by Seldinger technique in the surveillance of DSA, the obvious branches of the tumor blood supply were embolized by gelfoam particles. Size of tumor before and after chemotherapy was measured by gynecological examination combined with B ultrasonic examination and CT, then calculated the percentage of tumor regression. Radical hysterectomy was administered one month after chemotherapy. Results 24 patients were evaluated as PR, the reaction rate of chemotherapy was 92.3 %. Conclusion SACT before surgery can effectively reduce tumor volume, decrease lymphatic metastasis and subclinical dissemination and enhance the opportunity of radical hysterectomy, and to improve the quality of life and OS of the advanced cervical carcinoma patients.

关 键 词：子宫颈肿瘤 化疗疗法 肿瘤 局部灌注 

分 类 号：R737.33[医药卫生—肿瘤] R737.9[医药卫生—临床医学]