Lunx mRNA的表达与非小细胞肺癌外周血微转移的相关性研究  

The research on the relation between the expression of Lunx mRNA and micrometastasis of nonsmall cell lung cancer

作　　者：李辉[1] 刘铁梅[2] 孙景春[2] 孙晓盈[2] 谢风[2] 

机构地区：[1]吉林省人民医院,吉林长春130021 [2]吉林大学中日联谊医院

出　　处：《中国实验诊断学》2009年第4期487-489,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技发展计划项目资助课题(200705285)

摘　　要：目的研究Lunx mRNA的表达与非小细胞肺癌外周血微转移的相关性。方法采用RT-PCR(逆转录PCR)技术分别对实验组及对照组外周血Lunx mRNA的表达进行检测分析。结果NSCLC患者外周血微转移与病理类型、细胞分化程度及TNM分期均存在密切关系(P<0.05);NSCLC患者外周血微转移与年龄、性别、吸烟史、原发肿瘤部位无密切关系(P>0.05)。结论Lunx mRNA是一种检测NSCLC外周血微转移新型的、较好的特异性标记物,对判断病程发展和指导临床治疗具有重要意义。Objective To study the relation between the expression of Lunx mRNA and micrometastasis of nonsmall-cell lung cancer.Methods To detect the expression of Iamx mRNA in peripheral blood of the experimental and control groups by RT-PCR（reverse transcription PCR）. Results there are significant difference （ P 〈 0.05） between micrometastasis and pattologic-type, cell differentiation and TNM staging; there are significant difference（ P 〉 0.05） between micrometastasis and age,gender,smoking history and primaytumor position. Conclusion iamx mRNA is a new special tumor marker for the detecting micrometastasis of NSCLC, which is important for diagnosis, treat and prognostic judgement.

关 键 词：LUNX MRNA 非小细胞肺癌 微转移 RT-PCR 

分 类 号：R734.2[医药卫生—肿瘤]