DNA甲基转移酶1蛋白在膀胱移行细胞癌中的表达及其临床意义  

Expression of DNA methyltransferase 1 in transitional cell carcinoma of bladder

作　　者：管庆军[1] 刘春晓[1] 许凯[1] 郑少波[1] 李虎林[1] 徐亚文[1] 

机构地区：[1]南方医科大学珠江医院泌尿外科,广州市510282

出　　处：《实用医学杂志》2009年第8期1225-1227,共3页The Journal of Practical Medicine

摘　　要：目的:研究DNA甲基转移酶1(DNA methyltransferase1,DNMT1)在膀胱移行细胞癌(transitional cell carcinoma of the bladder,TCCB)组织中的表达及其与肿瘤生物学行为的关系。方法:应用免疫组织化学SP法检测60例TCCB组织中DNMT1的表达,结合临床资料,分析其与肿瘤生物学行为的相关性。结果:TCCB组织中DNMT1阳性表达率为(86.7%,52/60),明显高于癌旁组织(43.3%,26/60)及正常膀胱组织(33.3%,5/15)(P<0.01);DNMT1蛋白的阳性表达率与肿瘤分化程度和性别呈一定的相关性(P<0.01),与TCCB患者的年龄和临床分期无明显相关性(P>0.05)。结论:DNMT1蛋白过表达在人TCCB的发生和发展中起一定作用。Objective To investigate the expression of DNA methyltransferase 1 （DNMT 1） in transitional cell carcinoma of bladder （TCCB） and its relationship with oncobiology behaviour. Methods The expression of DNMT 1 in 60 TCCB specimens was detected by immunohistochemistry, and its correlations with oncobiology behavionr parameters were statistically analyzed. Results The positive rate of DNMT 1 was obviously higher in TCCB （86.7%, 52/60） than that in paracarcinoma tissue （43.3%, 26/60） or normal bladder tissue （33.3%, 5/15） （P 〈 0.01）, and was correlated with pathological grade of TCCB and patients＇ gender （P 〈 0.01 ）, but was not correlated with patients＇ age and clinical stage of TCCB （P 〉 0.05）. Conclusion Over-expression of DNMT 1 might play an important role in the development and progression of TCCB.

关 键 词：癌 移行细胞 DNA甲基转移酶1 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤] R735.34[医药卫生—临床医学]