食管癌加速超分割放疗的临床研究  

A Clinical Study of Accelerated Fractionation Radiotherapy for Esophagus Carcinoma

作　　者：师国珍[1] 李国文[1] 樊锐太[1] 庆明轩 宋振中[1] 郭有中[1] 郭跃信[1] 

机构地区：[1]河南医科大学第一附属医院放疗科

出　　处：《河南医学研究》1998年第1期62-64,共3页Henan Medical Research

基　　金：河南省医学科学院科研基金

摘　　要：目的：评价加速超分割放射治疗食管癌的疗效。方法：食管鳞癌９８例随机分为常规组和加速超分割组。常规组：１８０～２００ｃＧｙ／次，５次／周，总量６０００～７０００ｃＧｙ／６～７周；加速超分割组：１５０ｃＧｙ／次，２次／日，间隔６小时，总量５４００ｃＧｙ／３５周。两组病人均采用６０Ｃｏ远距离外照射。结果：常规组１，３，５年生存率分别为４６％（２３／５０）、２０％（１０／５０）、１２％（６／５０）；加速超分割组１，３，５年生存率分别为７０８％（３４／４８）、３９６％（１９／４８）、２９２％（１４／４８），加速超分割组明显优于常规组（Ｐ＜００５），而两组放疗反应和并发症无明显差异。结论：加速超分割放疗能明显提高食管癌病人的生存率，但不增加放疗反应及并发症。Objective: To evaluate the effect of accelerated fractionation radiation therapy for esophagus carcinoma.Methods:98 patients with histologically proven squanous carcinoma of the esophagus were treated either by conventional radiotherapy at 180～200 cGy per day 5 times a week to total dose of 6000～7000 cGy in 6～7 weeks or by accelerated fractional regime consisting of 150 cGy twice a day with an interval of 6 hours between fractions to a total dose 5400 cGy/3.5 weeks.The same Cobalt 60 teletherapy machine was used in all the patients.Results: The 1,3 and 5 year survival rates of patients were 46%(23/50),20%(10/50),12%(6/50) in conventional radiotherapy group and 70.8%(34/48),396%(14/48),29.2%(14/48) (P<005) in accelerated fractional radiotherapy group.There was no significant difference in clinical symptoms in two groups.Conclusion:The preliminary results from our study has shown that accelerated fractionation schedule for radiotherapy of esophageal carcinoma can give better survival rate than conventional radiotherapy without increating the symptoms.

关 键 词：食管癌 加速超分割 放射治疗 

分 类 号：R735.105[医药卫生—肿瘤]