前列腺癌组织中E-钙粘蛋白和环氧化酶2表达的研究  

The expression of E-cad and COX-2 in prostatic carcinoma

作　　者：朱煊[1] 彭再如[2] 刘洋[2] 吕晨[2] 钟朝晖[2] 张选志[2] 

机构地区：[1]湖南省郴州市第一人民医院泌尿外科,423000 [2]中南大学湘雅二医院泌尿外科

出　　处：《现代泌尿生殖肿瘤杂志》2009年第2期98-101,共4页Journal of Contemporary Urologic and Reproductive Oncology

摘　　要：目的探讨E-钙粘蛋白、环氧化酶2因子与前列腺癌病理分级及临床分期的关系。方法采用免疫组织化学SABC方法检测32例前列腺癌患者和24例良性前列腺增生标本中E-钙粘蛋白、环氧化酶2的表达。结果两组标本中E-钙粘蛋白在前列腺癌标本中的阳性表达率21.88%,在良性前列腺增生标本中的阳性表达率91.67%;而环氧化酶2在前列腺癌标本中的阳性表达率90.63%,在前列腺增生标本的阳性表达率37.50%。E-钙粘蛋白在高分化前列腺癌中的表达高于低分化前列腺癌;在A期和B期前列腺癌中的表达高于C期和D期的前列腺癌。环氧化酶2在低分化前列腺癌中的表达高于高分化前列腺癌;而在C期和D期的前列腺癌中的表达高于A期和B期前列腺癌。结论E-钙粘蛋白在前列腺癌标本中的表达明显低于前列腺增生标本,环氧化酶2的表达与此相反;两者在前列腺癌的表达与前列腺癌的病理分级及临床分期有关。Objective To investigate the expression of E-cadherin（E-cad） and cycloxygenase 2 （COX-2）in the prostatic carcinoma （PCa）and analysis the ralationship of the two factors result and the pathologic grading,clinical stages of cancer. Methods Thirty-two paraffin sections of PCa pa- tients and 24 paraffin sections of benign prostatic hyperplasia（BPH） patients had been chosen. Immunohistochemistry SABC method was employed to detect the expression of E-cad and COX-2 in all sections. Results The E-cad expression rates in PCa group is 21.88% ,in BPH group is 91.67%. The COX-2 expression rates in PCa group is 90.63%,in BPH group is 37.50%. The E-cad expression rates on the clinical stage A and B PCa sections is obviously higher than those on stage C and D. Contrarily the COX-2 expression rates on the clinical stage A and B PCa sections is obviously lower than those on stage C and D. Conclusions The E-cad expression rates in PCa group are lower than BPH group and the COX-2 expression rates in PCa group are higher than BPH group. The expression rates of E-cad and COX-2 in PCa sections correlate with the pathologic grading of cancer and clinical stages.

关 键 词：前列腺肿瘤 钙粘着糖蛋白类 前列腺素内过氧化物合酶 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤] R735.2[医药卫生—临床医学]