津血源颗粒对干燥综合征(SS)鼠的实验研究  

Empirical Study of Sicca Syndrome(SS) on Model Rats with Jinxieyuan Granula

作　　者：朱萱萱[1] 钱先[1] 倪文彭[1] 吴旭同[1] 丁扬[1] 苏梦[1] 

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《中华中医药学刊》2008年第12期2607-2609,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省科技厅资助课题(BK2007176)

摘　　要：目的:探讨津血源颗粒对干燥综合征(SS)模型鼠的治疗作用。方法:采用弗氏完全佐剂和百日咳、白喉、破伤风联合疫苗+同种鼠颌下腺抗原诱导,同时每天以0.6mg/kg利血平与50mg/kg甲状腺素灌胃,连续4周,建立类似临床SS动物模型。以津血源颗粒对SS模型鼠进行干预,观察津血源颗粒对SS模型鼠唾液分泌功能、体重、摄食量、饮水量、胸腺和颌下腺指数的影响。结果:津血源颗粒可以增加SS模型鼠的进食量、体重和唾液分泌量,缓解其口干症状,减少其饮水量,延缓SS模型鼠胸腺和颌下腺萎缩。结论:津血源颗粒可明显改善SS模型鼠的症状,对SS具有一定的治疗作用。Objeetive：To study the therapeutic action of healing sicca syndrome（SS） on model rats with Jinxieyuan Granula.Methods：use Freund＇s complete adjuvant,pertussis,diphtheria,tetanus combined vaccine and glandula angularis of the same race rats antigen derivation.Supply intragastric administration with 0.6mg/kg apoplon and 50mg/kg tetraiodothyronine to establish animal model of clinical SS.Interfere in SS model rats with Jinxieyuan Granula and observe its effect on SS model rats with salivary secretion function,body weight,food-intake,watere-intake and the exponent of thoracic gland and glandula angularis.Results：Jinxieyuan Granula can increase food-intake,body weight and salivary secretion of model rats.It also can elieve dry mouth symptom,decrease watere-intake and delay the analosis of thoracic gland and glandula angularis on model rats.Conclusion： Jinxieyuan Granula can obviously improve the symptom of SS model rats.It has positive therapeutic action with SS.

关 键 词：干燥综合征 津血源颗粒 SS症状 

分 类 号：R-33[医药卫生] R442.8