后程X-刀治疗DP方案化疗后无进展局部晚期非小细胞肺癌的疗效  

Effects of Late Course X-knife Radiotherapy on Local Advanced Non-small Cell Lung Cancer without Progression after DP Regimen Chemotherapy

作　　者：陈尚忠[1] 徐宁红[1] 曹杰红[1] 袁志华[1] 

机构地区：[1]湖南娄底市中心医院肿瘤科,417000

出　　处：《肿瘤防治研究》2009年第4期331-333,共3页Cancer Research on Prevention and Treatment

摘　　要：目的探讨序贯后程X刀治疗多烯紫杉醇加顺铂(DP方案)4周期化疗后无进展局部晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及不良反应。方法57例4周期DP方案化疗后无进展患者随机分为两组,常规组行常规分割照射,2Gy/次、1次/日,5次/周,总量64Gy;后程X刀组前四周治疗同常规组,4周后改用X刀,6Gy/次,3次/周,共6次,总量76Gy。比较两组的疗效及副作用。结果后程X刀组完全缓解率38.7%,高于常规组15.4%(P=0.047),后程X刀组三年生存率35.5%高于常规组15.4%(P=0.035),两组不良反应差异均无显著性。结论与常规放射治疗相比,序贯后程X刀治疗可提高化疗后无进展局部晚期NSCLC患者的完全缓解率及三年生存率,不良反应未增加,可作为化疗后无进展NSCLC患者的主要治疗手段。Objective To evaluate the effects of substantial late course X-knife radiotherapy on local advanced non-small lung cancer （NSCLC） without progression after four cycles of docetaxel plus cisplatin （DP regimen）, and to observe adverse events. Methods A total of 57 NSCLC patientswho received four cycles of DP regimen without disease progression were randomly divided into two groups. The first group includes the patients in conventional radiotherapy group receiving conventional fractionated radiotherapy by 2 Gy/fraction, 1 fraction/day, 5 fractions/week to a total dose of 64 Gy. The other includes those in X-knife group received conventional radiotherapy for 4 weeks with the same schedule as conventional radiotherapy group, then received X-knife radiotherapy by 6 Gy/fraction, 3 fractions/week to a total dose of 76 Gy. The responses and adverse events between these two groups were compared. Results The complete remission （CR） rate was significantly higher in X-knife group than in conventional radiotherapy group （38.7% vs. 15.4%, P = 0. 047）. The 3 year survival rate was also significantly higher in X-knife group than in conventional radiotherapy group （35.5% vs. 15.4%, P = 0. 035）. There was no signifi cant difference in the occurrence of adverse events between these two groups. Conclusion Comparing with conventional radiotherapy, substantial late course X knife radiotherapy could improve complete remission and long-term survival of local advanced NSCLC patients without progression after chemotherapy, without increasing adverse events; it can be recommended as standard treatment for local advanced NSCLC.

关 键 词：化疗 后程 X-刀 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]