肝癌患者血清α-L-岩藻糖苷酶检测及临床意义  

Test for αLfucosidase in hepatocellular carcinoma and its clinical significance

作　　者：葛鑫[1] 邓军[1] 魏德善 潘丽 

机构地区：[1]蚌埠医学院附属医院检验科

出　　处：《蚌埠医学院学报》1998年第2期127-128,共2页Journal of Bengbu Medical College

摘　　要：目的：评价和验证αＬ岩藻糖苷酶（ＡＦＵ）检测的临床意义。方法：连续监测法检测良恶性肝病的ＡＦＵ活性。结果：４７例肝癌（ＰＨＣ），６５例急性肝炎，５９例慢性肝炎，４８例肝硬变，４３例消化道肿瘤，６０例正常对照组；其测值（ｘ±ｓ）分别是１５．５５±７．３９、７．０４±２．８５、６．３５±２．４７、６．４４±２．６５、６．２８±２．５６和６．１５±１．４２Ｕ／Ｌ。ＰＨＣ组与其他各组间差异有显著性（Ｐ＜０．０１），其ＰＨＣ组阳性率为８０．８５％，ＡＦＵ法的特异性为９２．００％，与终点法比较，差异无显著性。结论：连续监测法检测ＡＦＵ速度快，精度高，是ＡＦＰ的良好互补手段。Objective:To evaluate the clinical significance of αLfucosidase(AFU).Methods:Continuous detection was made to measure the serum activity of AFU in patients of different hepatic diseases.Results:The value(x±s) of 47 cases of primary hepatocellular carcinoma(PHC),65 cases of acute hepatitis,59 cases of chronic hepatitis,48 cases of hepatocirrhosis,43 cases of gastrointestinal neoplasms and 60 normal controls were 15.58±7.39,7.04±2.85,6.35±2.47,6.44±2.65,6.28±2.56,6.15±1.42 U/L,respectively.The activity of AFU in PHC group were significantly higher than that of the other groups(P<0.01).The positive rate and specificity of PHC group were 80.85%,92.00% respectively.No difference existed between the terminal and continuous method.Conclusions:Continuous detection method of AFU has advantage of high speed and precision.It is a good complementary measurement to αFP and very valuable for clinic.

关 键 词：肝肿瘤 诊断 岩藻糖苷酶 AFU 

分 类 号：R735.704[医药卫生—肿瘤]