NF-κB/p65在鼻NK／T淋巴瘤中的表达及意义  

Study on expression of NF-κB/p65 in nasal NK/T cell lymphomas

作　　者：梁群英[1] 冯爱菊[1] 贺森[1] 刘秀芹[1] 刘亚[1] 

机构地区：[1]河南省商丘市第一人民医院病理科,河南商丘476100

出　　处：《中国医师杂志》2009年第4期477-479,共3页Journal of Chinese Physician

摘　　要：目的探讨NF-κB／p6S在鼻NK／T淋巴瘤表达及其与细胞凋亡和预后的关系。方法应用免疫组织化学SP法和TUNEL法，检测23例鼻NK／T淋巴瘤和14例良性淋巴结病变中NF-κB／p6S的表达水平和细胞凋亡。结果NF-κB／p65在鼻NK／T淋巴瘤表达的阳性率为43．5％（10／23）；凋亡指数与NF-κB／p65呈负相关（r=-0．631，P〈0．05）。NF-κB/p65阳性表达者的平均生存时间明显短于阴性者（P〈0．05）。结论NF-κB／p65表达而引起的凋亡抑制可能在鼻NK／T淋巴瘤的发生发展中有重要作用并可作为预后不良的参考指标。Objective To investigate the expression of NF-κB/p65 in nasal NK/T cell lymphomas. Methods Immunohistochemistry and TUNEL were used to study the expression of NF-κB/p65 and cell apoptosis in 23 nasal NK/T cell lymphoma samples and 14 benign lymph node lesions. Results The NF-κB/p65 positive rates were 43.5% （ 10/23 ）. The expression of NF-κB/p65 was negative correlated with apoptotic index among 23 nasal NK/T cell lymphomas（P〈0. 05）. The mean survival period in patients expressed NF-κB/p65 was significantly shorter than that in negative group （P〈0.05）. Conclusions Apoptosis inhibited by overexpression of NF-κB/p65 might be involved in the development of nasal NK/T cell lymphoma. NF-κB/p65 expression may be an unfavorable prognostic factor of nasal NK/T cell lymphoma.

关 键 词：NF-κB/生物合成 癌基因蛋白质p65(gag-jun)/生物合成 鼻肿瘤/代谢 淋巴瘤 T细肜代谢 

分 类 号：R73[医药卫生—肿瘤]