多奈哌齐治疗脑卒中后失语的疗效观察  

Therapeutic effect of Donepezil in the Treatment of Post-stroke Aphasia

作　　者：周刚[1] 朱祖福[1] 高志强[1] 

机构地区：[1]东南大学医学院附属江阴医院,江苏省江阴市214400

出　　处：《职业与健康》2009年第9期997-998,共2页Occupation and Health

摘　　要：目的探讨多奈哌齐治疗脑卒中后失语的疗效和安全性。方法脑卒中后失语患者62例,随机分为多奈哌齐治疗组(31例)及对照组(31例)。治疗组给予多奈哌齐5mg,1次/d,共8周;对照组用安慰剂(维生素C)1片,1次/d,采用西方成套测验(WAB)和交流能力问卷(CAL)评定患者语言功能和日常生活交流能力。结果治疗后,治疗组WAB、CAL评分明显高于治疗前,与对照组相比,WAB中的口语表达、听理解、复述、命名,均有统计学意义(t值分别为2.70,4.32,2.57,4.53,均P<0.01),CAL分值差异亦有统计学意义(t=2.89,P<0.01)。治疗组无明显不良反应。结论多奈哌齐治疗卒中后失语安全有效。[ Objective] To discuss the efficacy and safety of donepezil in the treatment of post-stroke aphasia. [ Methods ] 62 patients with post-stroke aphasia were divided into donepezil group （ n =31） and control group （ n =31 ） randomly. The patients of donepezil group were given 5mg donepezil once a day for 8 weeks, and the control group was treated with 1 tablet vitamin C once a day. The language function and communication ability in daily life of patients were evaluated by WAB and CAL. [ Results ] The WAB and CAL scores of donepezil group in post-treatment were higher than that in pre-treatment. There were significant differences in WAB scores （oral expression, auditory comprehension, retelling and naming } between donepezil group and control group （ t = 2.70,4.32,2.57,4.53, P 〈 0. 01 }. The difference in CAL score was significant （ t = 2.89, P 〈 0.01 ）. There was no obvious adverse reaction in donepezil group. [ Conclusion] Donepezil is effective and safety in the treatment of stroke aphasia.

关 键 词：多奈哌齐 脑卒中后 失语 

分 类 号：R743.3[医药卫生—神经病学与精神病学]