MicroRNA调控动物脂肪细胞的分化  

MicroRNAs Regulate Animal's Adipocyte Differentiation

作　　者：李国喜[1,2] 宁小敏[1] 康相涛[2] 杨公社[1] 

机构地区：[1]西北农林科技大学动物脂肪沉积与肌肉发育实验室,陕西杨凌712100 [2]河南农业大学牧医工程学院,河南郑州450002

出　　处：《中国生物化学与分子生物学报》2009年第4期321-326,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家高技术研究发展计划(863计划,No.2006AA10Z138)~~

摘　　要：MicroRNA(miRNA)属于非编码小调节RNA,在动物细胞的增殖、分化、凋亡和代谢等许多生物学过程中具重要作用.研究显示大量miRNA也参与动物脂肪细胞的分化调节,在前体脂肪细胞向成熟脂肪细胞的分化过程中具有多种功能.目前的研究结果表明,这些miRNA在脂肪细胞分化的早期或后期通过其靶基因发挥功能,如miR-17-92和miR-143分别通过其靶基因Rb2/p130和ERK5/BMK1调节脂肪细胞分化,过表达可促进体外培养的脂肪细胞分化.因此,了解更多miRNA在脂肪细胞分化中的功能,可以加深对动物脂肪形成分子机制的理解,并有可能将其作为脂类代谢性疾病治疗的潜在靶点.MicroRNAs （miRNAs） are small, non-coding regulatory RNAs that play important roles in many biological processes in mammalian cells, including proliferation, differentiation, apoptosis and metabolism. The present studies implicated that a number of miRNAs participated in the regulation of adipocyte differentiation and played various roles during the differentiation processes from pre-adipocyte to mature adipocyte. These miRNAs function through binding to the target genes at both early or later stage of differentiation. For example, the over-expression of miR-17-92 and miR-143 promote adipocyte differentiation in the cell culture systems by binding to target gene Rb2/p130 and ERK5/BMK, respectively. Therefore, understanding the functions of more miRNAs in adipocyte differentiation will help to explore the molecular mechanism of fat formation, and might lead to the discovery of potential therapeutic targets for lipid metabolic diseases.

关 键 词：MICRORNA 脂肪细胞 分化 

分 类 号：R363[医药卫生—病理学] Q74[医药卫生—基础医学]