抑郁症情绪日夜变化与若干生化指标  

Study on relationships among diurnal mood variation and some biochemical indexs in depressive patients

作　　者：刘晴晓[1] 孙静[2] 侯钢[2] 魏永越[1] 王筱兰[2] 尚晓芳[2] 史家波[2] 成为荣[2] 倪苏琳[2] 

机构地区：[1]南京医科大学,210029 [2]南京医科大学附属脑科医院精神科

出　　处：《临床精神医学杂志》2009年第2期77-79,共3页Journal of Clinical Psychiatry

基　　金：南京市科技发展项目(YKK06120)

摘　　要：目的:从抑郁症患者有无情绪日夜变化与血浆褪黑素(MLT)、β-内啡肽(β-EP)和神经肽Y(NPY)的关系。方法:18例无情绪日夜变化(无变化组)和36例有情绪日夜变化(有变化组)的抑郁症患者,40名正常对照者(对照组),在同一天6:30和16:30分别采血,分析血浆中MLT,β-EP,NPY浓度变化。结果:有变化组6:30血浆中MLT浓度高于对照组(P<0.05),两时间点血浆MLT浓度的差值低于对照组(P<0.05),有变化组两时间点血浆MLT浓度的差值与汉密尔顿抑郁量表(HAMD,24项)因子认知障碍间存在正线性相关关系(P<0.05)。整个患者组6:30血浆β-EP浓度与HAMD因子认知障碍间存在正线性相关关系(P<0.05)。无变化组16:30血浆NPY浓度与HAMD因子体质量减轻间存在负线性相关关系(P<0.05)。结论:抑郁症患者血浆褪黑素水平可能与情绪日夜变化存在密切关系。Objective：To detect the relationships among depressive patients with or without diurnal mood variention and melatonin （MLT） , beta-endorphin （β-EP） , and neuropeptide Y （ NPY ）. Method： The plasma level of MLT,β-EP and NPY were measured at 6：30 and 16：30 in a diel in depressive patients（ including 18 patients without diurnal mood variation and 36 patients with diurnal mood variation）and normal controls （n = 40）. Results ： Compared with controlled group, the plasma level of melatonin at 6 ： 30 and the differences be- tween the two points were higher and lower for patient group with diurnal mood variation, respectively（ P 〈 0.05 ）. The difference of the plasma level of melatonin between the two points was positively correlated to the factor score of recognition disturbance of Hamilton rating scale for depression（HAMD） （ P 〈 0.05 ）. There was a significantly positive relationship between the plasma level of beta-endorphin at 6：30 and the factor score of recognition disturbance of HAMD for the whole patients group（P 〈0.05 ）. The plasma level of neuropeptide at 16：30 was negatively correlated to the factor score of weight decrease of HAMD（ P 〈 0.05 ）for patient group without diurnal mood variation. Conclusion：The plasma level of melatonin may be correlated to the diurnal mood variation for patients with depression.

关 键 词：抑郁症 情绪日夜变化 褪黑素 beta-内啡肽 神经肽Y 

分 类 号：R749.4[医药卫生—神经病学与精神病学]