脑梗死患者血清MCP-1的变化及阿托伐他汀的干预作用  

Changes of serum MCP-1 in patients with acute cerebral infarction and intervention effect of atorvastatin

作　　者：王荔[1] 梅元武[1] 孙支唐[2] 宋丽云[2] 石娜[2] 李光来[2] 

机构地区：[1]华中科技大学同济医学院协和医院神经内科,武汉430022 [2]山西医科大学第二临床医学院神经内科

出　　处：《山西医科大学学报》2009年第4期344-346,共3页Journal of Shanxi Medical University

摘　　要：目的观察急性动脉粥样硬化性脑梗死患者血清中单核细胞趋化因子(MCP-1)水平及颈动脉粥样硬化斑块,研究MCP-1与缺血性卒中的关系,并探讨阿托伐他汀的抗炎作用。方法用ELISA法检测急性动脉粥样硬化性脑梗死患者79例(CI组)、短暂性脑缺血发作患者16例(TIA组)、正常对照组30例血清MCP-1水平,同时通过彩色多普勒超声检查颈动脉粥样硬化斑块,将有软斑块或血清低密度脂蛋白胆固醇(LDL-C)>2.6mmol/L的脑梗死患者分成A组(服用阿托伐他汀,n=21)和NA组(未用任何他汀类药物,n=23),治疗3个月后随访,观察两组血脂及血清MCP-1的变化。结果CI组及TIA组患者血清MCP-1水平较正常对照组显著升高(P<0.01)。治疗后A组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及血清MCP-1显著下降(P<0.01),NA组均无显著变化。治疗后A组与NA组血清MCP-1、TC及LDL-C比较差异有统计学意义(P<0.05)。结论MCP-1与缺血性卒中的发生有关,可能参与了脑梗死的免疫过程。阿托伐他汀可降低脑梗死患者TC、LDL-C及MCP-1水平,具有一定的抗炎作用。Objective To investigate serum level of monocyte chemoattractant protein-1 （ MCP-1 ） in patients, with acute atherothrombo- tic cerebral infarction, and to explore the anti-inflammation effect of atorvastatin. Methods The level of MCP-1 was determined in 79 patients with acute atherothrombotic cerebral infarction, 16 patients with transient ischemic attack （TIA）and 30 healthy controls by ELISA. The atherosclerotic plaques in the carotid artery were assessed by Doppler ultrasonography in all subjects. The patients with soft plaques or LDL-C 〉 2.6 mmol/L were divided into A group（ taking atorvastatin, n = 21 ）and NA group （not taking any statins, n = 23 ）. After followed up for 3 months, serum MCP-1 and cholesterol levels were measured in A group and NA group. Results The levels of MCP-1 in patients with acute cerebral infarction and TIA were significantly higher than that in controls. After treatment, the levels of TC,LDL-C,MCP-1 decreased significantly in A group（P 〈 0.01 ）, but not in NA group. The levels of MCP-1, TC and LDL-C showed significant difference after treatment between A group and NA group（P 〈 O. 05）. Conclusion Serum MCP-1 level is associated with the development of ischemic stroke, and may participate in the immune progress of cerebral infarction. Atorvastetin could have anti-in- flammation effect by decreasing the serum levels of TC, LDL-C and MCP-1 of patients with acute cerebral infarction.

关 键 词：脑梗死 动脉粥样硬化 单核细胞趋化因子-1 他汀类药物 

分 类 号：R743[医药卫生—神经病学与精神病学]