Chelerythrine chloride binding of guanosine in aqueous solution  

作　　者：Fan Liu Jian Bin Zhang Zheng Fu Zhang Xiao Yan Zhang Zuo Peng Du Xiong Hui Wei 

机构地区：[1]College of Chemical Engineering, Inner Mongolia University of Technology, Huhhot 010051, China [2]Department of Applied Chemistry, College of Chemistry & Molecular Engineering, Peking University, Beijing 100190, China

出　　处：《Chinese Chemical Letters》2009年第1期66-70,共5页中国化学快报（英文版）

基　　金：This project is financed by Jiangxi Boyuan Industry Co.,Ltd.(Jiangxi province,China)

摘　　要：In this work, the interaction between chelerythrine （CHE） and guanosine is studied using UV-vis and fluorescence measurements at various temperatures. The UV-vis spectra show that the increasing guanosine concentrations result in the decreasing absorption intensity and red shift of CHE E absorption band （267 nm）. The fluorescence spectra are fitted to linear analysis, yielding a binding constant of 1.04×10^4 L/tool at 298.15 K of CHE with guanosine. Besides, with △rHm^θ = - 8.26 kJ/mol, △rGm^θ = -22.90 kJ/mol, and △rSm^θ = 49.38 J/（mol K） the interaction should be entropy-driven and exterothermic.In this work, the interaction between chelerythrine （CHE） and guanosine is studied using UV-vis and fluorescence measurements at various temperatures. The UV-vis spectra show that the increasing guanosine concentrations result in the decreasing absorption intensity and red shift of CHE E absorption band （267 nm）. The fluorescence spectra are fitted to linear analysis, yielding a binding constant of 1.04×10^4 L/tool at 298.15 K of CHE with guanosine. Besides, with △rHm^θ = - 8.26 kJ/mol, △rGm^θ = -22.90 kJ/mol, and △rSm^θ = 49.38 J/（mol K） the interaction should be entropy-driven and exterothermic.

关 键 词：Chelerythrine （CHE） GUANOSINE UV-vis spectra Fluorescence spectra 

分 类 号：O647.2[理学—物理化学] S567.239[理学—化学]