Chitosan nanoparticles crosslinked by glycidoxypropyltrimethoxysilane for pH triggered release of protein  

作　　者：Ai Wu Pan Bei Bei Wu Jian Min Wu 

机构地区：[1]Department of Chemistry, Zhejiang University, Hangzhou 310027, China [2]Hospital of Zhefiang University, Hangzhou 310058, China

出　　处：《Chinese Chemical Letters》2009年第1期79-83,共5页中国化学快报（英文版）

摘　　要：pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate （TPP） and glycidoxypropyltrimethoxysilane （GPTMS）. Compared with TPP crosslinked chitosan particles, the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range. Fluorescein isothiocyanate （FITC） labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pH- responsive drug delivery materials.pH-responsive-chitosan nanoparticles for the control release of protein drug were prepared by combining two-step crosslinking method, in which chitosan was subsequently crosslinked by sodium tripolyphosphate （TPP） and glycidoxypropyltrimethoxysilane （GPTMS）. Compared with TPP crosslinked chitosan particles, the two-step crosslinked nanoparticles were not only pH-responsive but also more stable in wide pH range. Fluorescein isothiocyanate （FITC） labeled anti-human-IgG antibody was used as a model protein drug for evaluating the control release profile of the nano-carrier. The amount of released antibody increased from 5.6% to 50% when the pH of solution shifted from 7.4 to 6.0. The results suggest the possible application of the nanoparticles as pH- responsive drug delivery materials.

关 键 词：CHITOSAN NANOPARTICLES pH-response Drug delivery Controlled release PROTEIN 

分 类 号：O636.1[理学—高分子化学] TQ460.4[理学—化学]