ZNF217基因在卵巢癌中的表达及意义  

Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance

作　　者：孙桂芹[1] 钟梅[1] 丁彦青[2] 苏桂栋[1] 宋天蓉[1] 尹爱兰[1] 

机构地区：[1]南方医科大学南方医院妇产科,广东广州510515 [2]南方医科大学南方医院病理科,广东广州510515

出　　处：《南方医科大学学报》2009年第4期685-688,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(8151051501000035)

摘　　要：目的检测ZNF217基因在卵巢囊腺癌、卵巢囊腺瘤及正常卵巢组织中的表达,初步探讨其与卵巢癌发生发展的关系。方法用免疫组织化学法及实时RT-PCR方法检测卵巢囊腺癌、卵巢囊腺瘤及正常卵巢组织中ZNF217基因在蛋白及转录水平的表达情况。结果ZNF217基因在卵巢囊腺癌中的蛋白表达高于卵巢囊腺瘤及正常卵巢组织中的(P<0.05),而且ZNF217基因的蛋白高表达与卵巢癌的发生显著相关(r=0.627),卵巢囊腺瘤组织与正常的卵巢组织相比差异则无显著性(P>0.05),在mRNA水平的检测与上述结果一致。结论ZNF217基因的表达与卵巢癌的发生高度相关,且与卵巢癌的临床分期相关。ZNF217基因可能是导致卵巢癌发生发展的重要候选基因之一。Objective To explore the correlation of ZNF217 expression to the carcinogenesis and progression of human ovarian cancer. Methods Irnmunohistochemistry and real-time RT-PCR were used to detect ZNF217 expression in human ovarian cystadenocarcinoma, ovarian cystadenoma and normal ovary tissues. Results The expression levels of ZNF217 protein and mRNA in ovarian cystadenocarcinoma was significantly higher than those in matched ovarian eystadenoma and normal tissues （P〈0.05）. No significant difference was found in the expression between ovarian cystadenoma and normal ovarian tissues （P〉0.05）. The mRNA expression in the specimens was consistent with the protein expression of ZNF217 （P〈0.05）. Conclusion ZNF217 gene expression is closely correlated to the occurrence and clinical stages of ovarian carcinomas, suggesting that ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas.

关 键 词：ZNF217 卵巢癌 锌指蛋白 

分 类 号：R737.31[医药卫生—肿瘤]