Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor  

作　　者：Fei Ma Gang Lu Wei Fen Zhou Qiu Juan Wang Yi Hua Zhang Qi Zheng Yao 

机构地区：[1]School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2009年第4期420-422,共3页中国化学快报（英文版）

摘　　要：A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory activities similar to that of methotrexate （MTX）, while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory activities similar to that of methotrexate （MTX）, while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.

关 键 词：Nitric oxide TETRAHYDROBIOPTERIN Nitric oxide synthase SYNTHESIS Inhibitive activity 

分 类 号：TQ465.92[化学工程—制药化工] S852.3[农业科学—基础兽医学]