云南高校图书馆联盟文献共享服务平台- TETRAHYDROBIOPTERIN

TETRAHYDROBIOPTERIN: 作品数：14被引量：48H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：林怡君更多>>; 相关机构：台湾大学兰州大学第二医院华侨大学更多>>; 相关期刊：《China Medical Abstracts(Internal Medicine)》《Neuroscience Bulletin》《Acta Biochimica et Biophysica Sinica》《Asian Journal of Andrology》更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金更多>>

Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats被引量：1: 《Asian Pacific Journal of Tropical Biomedicine》2023年第7期287-295,共9页Yucinda YY Khor Siew-Keah Lee Dharmani Devi M Wei Chih Ling; funded by the Universiti Tunku Abdul Rahman Research fund(IPSR/RMC/UTARRF/2019-C2/L08)。; Objective:To investigate the effect of epigallocatechin-3-gallate(EGCG)on endothelial dysfunction in spontaneously hypertensive rats(SHR).Methods:Wistar-Kyoto(WKY)rats and SHR were divided into four groups;WKY control...; 关键词：Epigallocatechin-3-gallate Vascular protection ANTIHYPERTENSION TETRAHYDROBIOPTERIN Cyclic guanosine monophosphate Angiotensin typeⅠreceptor Spontaneously hypertensive rats

m^(6)A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels被引量：2: 《Cancer Communications》2022年第4期327-344,共18页Yinan Liu Ertao Zhai Junting Chen Yan Qian Risheng Zhao Yan Ma Jianqiu Liu Zhixin Huang Shirong Cai Jianhui Chen; Natural Science Foundation of Guangdong Province,Grant/Award Numbers:2018A030313634,2020A1515010214,2021A1515010473;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Numbers:2020A1515010214,2018A030313634,2021A1515010473;Young Teacher Foundation of Sun Yat-sen University,Grant/Award Number:19ykpy58;China Postdoctoral Science Foundation,Grant/Award Number:2020M683087。; Background:Methyltransferase 3(METTL3)-mediated N6-methyladenosine(m^(6)A)RNA modification has been demonstrated to be a potential factor in promoting gastric cancer(GC).METTL3 regulates a series of signaling pathways...; 关键词：BH_(4) gastric cancer GCH1 m^(6)A metabolism reprogramming METASTASIS METTL3 PBX1 PROLIFERATION

Combining Human and Rodent Genetics to Identify New Analgesics被引量：3: 《Neuroscience Bulletin》2018年第1期143-155,共13页Alban Latremoliere Michael Costigan; supported by NIH grant DE022912;supported by NIH grant NS074430; Most attempts at rational development of new analgesics have failed, in part because chronic pain involves multiple processes that remain poorly understood. To improve translational success, one strategy is to select ...; 关键词：Chronic pain GENETICS Mouse models TETRAHYDROBIOPTERIN Sepiapterin reductase ANALGESICS

Effects of tetrahydrobiopterin on the angiogenesis in hepatocellular carcinoma: 《China Medical Abstracts(Internal Medicine)》2017年第1期45-46,共2页代佑果; Objective To investigate the effect and mechanism of tetrahydrobiopterin(BH4)on the angiogenesis in hepatocellular carcinoma(HCC).Methods BALB/c-nu mice were subcutaneously injected with Hep G-2 cells and randomly div...; 关键词：Effects of tetrahydrobiopterin on the angiogenesis in hepatocellular carcinoma

Tetrahydrobiopterin Protects against Radiation-induced Growth Inhibition in H9c2 Cardiomyocytes被引量：11: 《Chinese Medical Journal》2016年第22期2733-2740,共8页Zheng-Yi Zhang Yi Li Rui Li An-An Zhang Bo Shang Jing Yu Xiao-Dong Xie; This work was supported by the National Natural Science Foundation of China （No. 81270332）, and Gansu Province Health Industry Scientific Research Plan （No. GSWSKY-2014-33）.; Background：Tetrahydrobiopterin （BH4） is an essential cofactor of nitric oxide synthases （NOSs） for the synthesis of nitric oxide （NO）.BH4 therapy can reverse the disease-related redox disequilibrium observed wi...; 关键词：Endothelial Nitric Oxide Synthase Oxidative Stress PROLIFERATION Radiation-induced Heart Disease TETRAHYDROBIOPTERIN

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase: 《Journal of Geriatric Cardiology》2015年第5期528-539,共12页Silke Tobias Alice Habermeier Daniel Siuda Gisela Reifenberg Ning Xia Ellen I Closs Ulrich Forstermann Huige Li; Objective To find out whether dexamethasone induces an uncoupling of the endothelial nitric oxide synthase （eNOS）. Methods ＆ Results A major cause of eNOS uncoupling is a deficiency of its cofactor tetrahydrobiopte...; 关键词：DEXAMETHASONE Endothelial cells eNOS uncoupling Nitric oxide synthase Reactive oxygen species TETRAHYDROBIOPTERIN

Antioxidants,inflammation and cardiovascular disease被引量：29: 《World Journal of Cardiology》2014年第6期462-477,共16页Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner; Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiolo...; 关键词：ATHEROGENESIS Cardiovascular disease NEOPTERIN Nitric oxide TETRAHYDROBIOPTERIN TRYPTOPHAN Oxidative stress HOMOCYSTEINE VITAMINS Antioxidative therapy

QDPR gene mutation and clinical follow-up in Chinese patients with dihydropteridine reductase deficiency: 《World Journal of Pediatrics》2014年第3期219-226,共8页De-Yun Lu Jun Ye Lian-Shu Han Wen-Juan Qiu Hui-Wen Zhang Jian-De Zhou Pei-Zhong Bao Ya-Fen Zhang Xue-Fan Gu; supported by grants from the Major Program of Shanghai Committee on Science and Technology(11dz1950300);the National Key Technology R&D Program(2012BAI09B04).; Background:This study aimed to investigate the mutation spectrum of the QDPR gene,to determine the effect of mutations on dihydropteridine reductase(DHPR)structure/function,to discuss the potential genotype-phenotype ...; 关键词：dihydropteridine reductase HYPERPHENYLALANINAEMIA TETRAHYDROBIOPTERIN

Tyrosine hydroxylase gene transfections to different sites of striatum in the rat model of Parkinson’s disease: 《Open Journal of Genetics》2013年第2期30-37,共8页Atso Raasmaja Sarka Lehtonen Tiina Kaariainen Pasi Lampela Marko Huotari Anne Lecklin; The use of gene therapy has been intensively studied as a potential method to treat Parkinson’s disease (PD) and other degenerative brain diseases. However, the effects of experimental measures and approaches on the ...; 关键词：Tyrosine Hydroxylase TETRAHYDROBIOPTERIN Adenovirus Vector 6-HYDROXYDOPAMINE Parkinson’s Disease Gene Therapy

Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor: 《Chinese Chemical Letters》2009年第4期420-422,共3页Fei Ma Gang Lu Wei Fen Zhou Qiu Juan Wang Yi Hua Zhang Qi Zheng Yao; A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory...; 关键词：Nitric oxide TETRAHYDROBIOPTERIN Nitric oxide synthase SYNTHESIS Inhibitive activity

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