p27、CyclinD1和Ki-67在乳腺导管癌中的表达及相关性分析  

Expression and correlation analysis of p27,CyclinD1 and Ki-67 in breast ductal carcinomas

作　　者：李会平[1] 邢鲁奇[1] 薛玲玲[1] 

机构地区：[1]河南科技大学第一附属医院病理科,河南洛阳471003

出　　处：《河南医学研究》2009年第1期26-28,共3页Henan Medical Research

基　　金：洛阳市应用技术研究与开发基金项目(0802021A)

摘　　要：目的:探讨乳腺导管癌中p27,CyclinD1和Ki-67蛋白的表达及意义。方法:采用免疫组化法探讨20例导管内癌、20例微浸润导管癌和40例浸润性导管癌组织中p27,CyclinD1和Ki-67蛋白的表达。结果:①在导管内癌、微浸润导管癌和浸润性导管癌组织中p27蛋白的高表达率呈递减趋势,CyclinD1和Ki-67的高表达率呈递增趋势。②p27,CyclinD1和Ki-67的高表达率在导管内癌、微浸润导管癌和浸润性导管癌中的差异有统计学意义(P<0.05);③不同阶段乳腺导管癌中p27与CyclinD1/Ki-67的高表达率均呈负相关。结论:p27在乳腺导管癌的发生发展中可能起明显的抑制作用,联合检测p27与CyclinD1/Ki-67对反映乳腺导管癌的恶性程度以及预后可能更为客观。Objective： To explore the expression and significances of p27, CyclinD1 and Ki-67 in breast ductal carcinomas. Methods： The expression of p27, CyelinD1 and Ki-67 was detected in 20 cases of intraductal carcinomas, 20 cases of miero-invasive ductal carcinomas and 40 cases of invasive breast ductal carcinomas by immunohistochemistry. Results： ①The high-expression rates of p27 in intraduetal carcinomas, micro-invasive ductal carcinomas and invasive breast duetal carcinomas were gradually decreased. The high-expression rates of CyclinD1 and Ki-67 were gradually increased. ②The high-expression rates of p27, CyclinD1 and Ki-67 in intraductal carcinomas, micro-invasive ductal carcinomas and invasive breast ductal carcinomas had significance of statistics （P 〈 0.05 ）. ③The high-expression rates of p27 and CyelinD1/Ki-67 protein were inversely correlated in different stages of breast ductal carcinomas. Conclusion ： Abnormal high-expression of p27 may play an suppressive role in initiation and development of breast ductal carcinomas. The cornbined analysis of p27 and CyclinD1/Ki-67 expression is considered to be more reliable for assessing the histopathologic grades and prognosis of breast ductal carcinomas.

关 键 词：P27 CYCLIND1 乳腺导管癌 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]