生物干预辅助颅颌骨缝改建的研究进展  

Biological approaches to modification of craniofacial sutures

作　　者：张蕾[1] 徐子卿[1] 唐国华[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔正畸科.上海市口腔医学重点实验室.上海200011

出　　处：《上海口腔医学》2009年第2期211-217,共7页Shanghai Journal of Stomatology

基　　金：国家自然科学基金(30500572);上海市科学技术委员会资助项目(06QA14031)~~

摘　　要：颅颌面骨的生长主要依赖于骨缝区新骨的沉积,并受到周围机械应力的影响,这是使用正畸力或矫形力治疗颅面部生长发育异常的生物学基础。不同特性的应力刺激,如牵张力/压缩力、轻力/重力、持续力/间断力,通过促进或抑制局部特定生长因子的表达来调控骨缝区的骨形成和骨改建。近年来的研究显示,在施加机械力的同时使用物理干预或局部应用各种生物制剂,可辅助调控骨缝区的骨改建。了解骨缝组织在不同生物干预途径下的组织学改变及生物学反应规律,将有利于正确理解颅面部生长改建的机制,同时为临床选择合理的颅面部畸形的正畸治疗模式提供科学依据,并对寻求缩短疗程、增加疗效的治疗方法有着重要的参考价值。The new bone deposition along the craniofacial sutures contributes to the overall growth of the craniofacial complex. The osteogenesis in suture is also regulated by the surrounding mechanical stress, which is the basis that orthodontic or orthopedic forces could therapeutically correct craniofacial growth abnormalities. Applying different kinds of mechanical forces, such as stretching/compression force, light/heavy force, continuous/intermittent force, could modulate the process of new bone formation in suture, by regulating the expression of a contain of growth factors. Recent researches indicated that additional biological manipulation, like physical stimulation and local administration of growth factors, could further assist the growth modification of suture upon mechanical forces. Understanding the tissue and molecular events of bone regeneration in suture upon different biological approaches could have important implications for the clinical management of eraniofacial development and growth. Supported by National Natural Science Foundation of China （Grant No. 30500572） and Research Fund of Science and Technology Commission of Shanghai Municipality （Grant No.06QA14031）.

关 键 词：颅颌骨缝 机械应力 生物干预 生长改建 成骨细胞 

分 类 号：R783.5[医药卫生—口腔医学]