MS23对大鼠的不同器官血管环收缩的影响  

Effects of MS23 on KCl^-,α-adrenoceptor agonists-and U46619-induced contractions of arteries isolated from rat different organs

作　　者：刘宇[1] 张明升[1] 王德锁 刘丹冰[1] 薛文鑫[1] 牛龙刚[1] 梁月琴[1] 

机构地区：[1]山西医科大学药理学教研室,山西太原030001 [2]College of Pharmacy of University of South Carolina, Columbia, SC 29208

出　　处：《中国药理学通报》2009年第4期506-510,共5页Chinese Pharmacological Bulletin

基　　金：山西省自然科学基金资助项目(No20051113)

摘　　要：目的研究MS23对不同激动剂所致不同部位血管收缩的对抗作用或舒张作用。方法大鼠主动脉环和小动脉环的张力舒缩状态分别采用PowerLab和DMT系统记录。结果MS23浓度依赖性抑制去甲肾上腺(NA)引起的主动脉环收缩,使NA浓度-效应曲线非平行性右移,并抑制最大反应,使最大效应下降74.7%。MS23和氨茶碱对高钾和NA引起的大鼠主动脉环预收缩均表现出浓度依赖性舒张效应。去内皮和一氧化氮合酶抑制剂L-NAME对MS23的血管舒张作用无明显影响。小动脉环实验结果为,MS23和氨茶碱浓度依赖性舒张高钾所致大鼠冠状动脉、大脑中动脉、肾动脉和肠系膜动脉环的收缩,此4脏器的小动脉对此二药舒张作用的敏感程度差异均无显著性。结论MS23对多种刺激引起的血管环收缩具有对抗或舒张作用,对血管来源和刺激剂无明显的选择性。其血管舒张作用与NO产生及血管内皮是否存在无关。Aim To study the vasodilation of MS23, a brand new phosphodiesteras inhibitor, on contractions induced by various stimuli in tings of arteries isolated from rat different organs. Method Tension of aortic and microvessel tings were recorded isometrically by PowerLab and DMT system respectively. Results MS23 concentration-dependently shifted the noradrenaline （NA）-induced concentration-contraction curves rightward in a non-parallel manner with the maximal contraction depressed by 74.7%. MS23 and aminophylline （Ami） produced concentration-dependent relaxation on KCl or NA-induced precontraction. Endothelium deprivation and NO synthesis inhibition in-duced by L-NAME failed to affect the relaxation. MS23 and Ami relaxed KCl-induced precontraetion of rat coronary, middle cerebral, renal and mesenteric arterial tings in a concentration-dependent manner, and showed no organ preference in this respect. Conclusion MS23 antagonizes and relaxes contractions induced by various stimuli in the rings of arteries isolated from different organs of rat without marked preference among the organ origin of artery and stimuli. The vasorelaxation induced by MS23 is related neither to endothelium nor to nitric oxide synthesis.

关 键 词：MS23 动脉血管环 血管收缩 血管舒张 磷酸二酯 酶抑制剂 

分 类 号：R-332[医药卫生] R322.121