卡莫司汀-聚乳酸缓释膜片植入家犬脑内的药代动力学研究  

Pharmacokinetics of BCNU-PLA Delayed Release Wafer Embedded in Brain of Dogs

作　　者：卜国云[1] 王金环[2] 杨忠旭[1] 徐新女[2] 刘宏胜[2] 王文治[3] 

机构地区：[1]天津市第四中心医院神经外科,天津市300140 [2]天津市第一中心医院卫生部急救医学重点实验室,天津市300192 [3]天津市第一中心医院神经外科,天津市300192

出　　处：《中国康复理论与实践》2009年第4期324-326,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：天津市自然科学基金重点项目(No.023803911)

摘　　要：目的观察卡莫司汀(BCNU)-聚乳酸(PLA)缓释膜片植入家犬脑内的药代动力学特征及BCNU在脑组织中的浓度。方法制备10%BCNU-PLA缓释膜片,并将其植入12只家犬脑内,术后采集不同时间外周血样并处死家犬采集脑组织,采用高效液相色谱法测定血药浓度和脑组织药物浓度。结果术后22h家犬血中可测到BCNU,35h达到峰值(平均243.64ng/ml)。术后5d脑组织中药物浓度平均26.60μg/g。结论BCNU-PLA缓释膜片是治疗恶性胶质瘤的一个良好剂型。Objective To observe the pharmacokinetics and concentration of 1,3 bis （2 chloroethyl）-1-nitrosourea （BCNU） in brain tissue after BCNU-polylactic acid （PLA） delayed release wafer embedded in brain tissues of dogs. Methods 10% BCNU-PLA delayed release wafer were prepared and embedded in brains of 12 dogs. Peripheral blood of dogs was taken and the animals were executed for brain tissue after surgery in different times. BCNU concentrations in blood and brain tissue were quantified by high-performance liquid chromatography. Results BCNU was able to be detected at 22nd hour, and the Cmax （average 243.64 ng/ml） appears at 35th hour after surgery. The average BCNU concentration in brain tissue was 26.60μg/g at 5th day after surgery. Conclusion BCNU-PLA delayed release wafer is a useful type for treatment of malignant gliocoma.

关 键 词：卡莫司汀-聚乳酸缓释膜片 高效液相色谱法 家犬 

分 类 号：R739.41[医药卫生—肿瘤]