多西紫杉醇联合奥沙利铂和5-氟尿嘧啶治疗晚期胃癌33例临床观察  

Clinical observation of docetaxel combined with oxaliplatin and 5-fluorouracil in the treatment of 33 cases with advanced gastric cancer

作　　者：史会昌[1] 周学义[1] 薛玉保 

机构地区：[1]淮安市第二人民医院肿瘤科,江苏淮安223002

出　　处：《徐州医学院学报》2009年第4期266-268,共3页Acta Academiae Medicinae Xuzhou

摘　　要：目的考察多西紫杉醇联合奥沙利铂、5-氟尿嘧啶和亚叶酸钙方案治疗晚期胃癌的临床效果。方法33例晚期胃癌患者给予多西紫杉醇35 mg/m2(第1天,第8天,第15天),奥沙利铂85 mg/m2(第1天,第8天),5-氟尿嘧啶500 mg/m2(第1天至第5天),28天为1周期,疗程4周期。结果33例患者中完全缓解3例,部分缓解16例,稳定10例,进展4例,总有效率57.58%;中位疾病进展时间为5.12个月,常见的毒性反应为白细胞和中性粒细胞减低,消化道反应和周围神经毒性反应等。结论多西紫杉醇联合奥沙利铂、5-氟尿嘧啶及亚叶酸钙化疗方案治疗晚期胃癌的疗效显著,毒性反应患者能耐受,可能延长患者生存期。Objective To evaluate the clinical efficacy of the regimen of docetaxel combined with oxaliplatin, 5 - fluorouracil and calcium folinate in the treatment of advanced gastric cancer. Methods 33 patients with advanced gastric cancer were injected with docetaxel 35 mg/m^2 （day 1, 8 and 15） , oxaliplatin 85 mg/m2 （day 1 and 8 ） and fluorouracil 500 mg/m^2 （ 1 - 5 d） for 4 cycles, with every 28 days in a cycle. Results Of 33 patients, 4 cases had complete remission, 17 cases had partial remission, 6 cases had stable disease and 6 cases had progressive disease, with the total response rate of 57.6%, and the median time to progression was 5.12 month. The most common adverse reactions included leucopenia, neutronpenia, gastrointestinal tract reactions （nausea, vomit and diarrhea） and peripheral neuropathy, etc. Conclusion The regimen of docetaxel combined with oxaliplatin, 5 - fluorouracil and calcium folinate in the treatment of advanced gastric cancer has remarkable response rate and tolerable toxicity, which may contribute to the prolonged survival of the patients.

关 键 词：多西紫杉醇 奥沙利铂 5-氟尿嘧啶 晚期胃癌 

分 类 号：R735.2[医药卫生—肿瘤]