短暂性脑缺血发作患者血清抵抗素与高敏C-反应蛋白的水平变化与脑血栓形成的关系  

Changes of the serum levels of resistin and Hs - CRP between transient ischemic attack and cerebral infarction

作　　者：周永勤[1] 黄友敏[2] 王霞[3] 徐强[1] 张国庆[1] 

机构地区：[1]济宁医学院附属滕州市中心人民医院ICU,277500 [2]济宁医学院附属滕州市中心人民医院检验科,277500 [3]济宁医学院附属滕州市中心人民医院耳鼻喉科,277500

出　　处：《中国实用医刊》2009年第9期5-7,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察短暂性脑缺血发作（TIA）患者抵抗素与高敏-C反应蛋白（Hs—CRP）的水平，并探讨抵抗素和Hs—CRP与脑梗死的关系。方法将120例TIA患者按照病程发展划分为三组：即TIA在60min内完全缓解者为A组，TIA持续60min以上但最后完全恢复者为B组，TIA起病后发展为脑梗死为C组；60例健康体检者作为对照组。所有病例在起病24h内首次测定血清抵抗素和Hs—CRP，并观察72h内头颅CT或MRI后进行相关性分析研究。结果C组抵抗素和Hs—CRP高于A和C组（P〈0．01），而A、B组之间差异也有统计学意义（P〈0．05）。血清抵抗素和Hs—CRP呈正相关（r=0．63，P〈0．01）。结论抵抗素和Hs—CRP水平的升高与脑组织受损有关，抵抗素和Hs—CRP检测对治疗及估计预后有指导意义。Objective To survey the serum levels of resistin and high sensitivity C - reactive protein （Hs- CRP） in transient ischemic attack patients, and to assess the correlation between resistin, Hs- CRP and cerebral infarction. Methods One hundred and twenty TIA patients were divided into three groups, TIA could be relieved in 60 minutes （group A）, TIA could be relieved completely more than 60 minutes （group B） and TIA deteriorated into cerebral infarction （group C ）. 60 healthy human were as control group. Resistin and Hs -CRP were measured within 24 hours. Head CT and MRI were carried out within 72 hours, then we did the relative analysis research. Results The serum resistin and Hs - CRP levels of C group was higher than group A and B（ P 〈0.01 ）, and the levels was different obviously between group A and B （P 〈 0.05 ）. The correlative analysis of all groups demonstrated that serum resistin and Hs - CRP had obvious positive relationship（ r =0.63, P 〈0. 01 ）. Conclusions The rise of resistin and Hs - CRP have something with the damage of brain. The rise of Hs - CRP is instructive significance in treating and estimating prognosis.

关 键 词：短暂性脑缺血发作 脑梗死 抵抗素 高敏-C反应蛋白 

分 类 号：R74[医药卫生—神经病学与精神病学]