微电极记录在脑深部电刺激术治疗肌张力障碍中的应用  

Microelectrode recording guided implantation of deep brain stimulators in the treatment of dystonia

作　　者：邬剑军[1] 郎黎琴[2] 潘力[2] 陈嬿[1] 

机构地区：[1]复旦大学华山医院神经内科,上海200040 [2]复旦大学华山医院神经外科,上海200040

出　　处：《中国神经精神疾病杂志》2009年第4期220-222,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的评价微电极记录在脑深部电刺激手术中的应用价值。方法21岁的年轻女性,进行性肌张力障碍病史6年,从颈部向四肢发展,曾经行肉毒杆菌素治疗,半年后症状重新出现。MRI定位后行双侧苍白球内侧部刺激手术,术中通过微电极记录确定靶点指导手术。结果在不同深度,微电极记录到不同脑组织的放电频率和幅度,根据放电频率和幅度的差异,指导电极精确定位。术后行MRI检查显示定位准确。术后1个月开机,肌张力障碍功能评分症状显著改善(从40降至7)。结论深部脑刺激术过程中的微电极记录能够指导手术定位。Objective To evaluate the technique of microelectrode recording approach for deep brain stimulation in the treatment of dystonia. Methods Bilateral, stereotactic, microelectrode-guided placement of pallidal deep brain stimulators were carried out at a 21-year-old girl who suffered progressive dystonia for 6 years. Results The microelectrode reached the target exactly by recording firing of various frenquency and amplitude in different brain locations. Postoperative MRI of the brain verified the accuracy of the stimulators. One month after generator implantation, the patient＇s unified dystonia rating scale （UDRS） decreased from 40 to 7. Conclusions Intraoperative microelectrode recording is useful to help confirm correct placement of the deep brain stimulators lead.

关 键 词：微电极记录 脑深部电刺激 肌张力障碍 苍白球内侧部 

分 类 号：R746[医药卫生—神经病学与精神病学]