AKT／PKB通路在非小细胞肺癌中作用的研究进展  

Research development of AKT/PKB pathway in non-small cell lung cancer

作　　者：蒲蓉[1] 李为民[1] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041

出　　处：《国际呼吸杂志》2009年第8期493-496,共4页International Journal of Respiration

摘　　要：AKT／蛋白激酶B（protein kinase B，PKB）是一种丝氨酸／苏氨酸蛋白激酶，传递生长因子等胞外刺激信号，参与调节细胞凋亡、增生、分化和代谢等一系列生理活动。目前在肿瘤的研究中发现AKT／PKB的激活与肿瘤的发生、发展以及肿瘤血管的形成都有密切的关系。本文就AKT／PKB通路在非小细胞肺癌中作用的研究进展进行综述。AKT/protein kinase B（PKB） is a kind of serine/thyring kinases. It plays a role in the transportation of extraeellular stimuli signal, such as growth factor, and participates in a series of physiological activities, such as cell apoptosis, proliferation, differation and metabolism. At present, many researches show AKT/PKB has close relationship with tumor genesis, development and angiogenesis. The article reviews the role of AKT/PKB pathway in non-small cell lung cancer.

关 键 词：AKT/PKB 磷酸化 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤] R163[医药卫生—临床医学]