绝经前后妇女血清IGF-1水平与乳腺癌发病危险度的Meta分析  

Meta-analysis of risk factors between level of insulin-like growth factor-1 and breast cancer in pre-and postmenopausal women

作　　者：朱志[1] 徐惠绵[1] 刘群[2] 郑新宇[2] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科中国医科大学附属第一医院普通外科教研室胃肠肿瘤外科,辽宁沈阳110001 [2]中国医科大学附属第一医院肿瘤外科中国医科大学附属第一医院普通外科教研室乳腺外科,辽宁沈阳110001

出　　处：《中华肿瘤防治杂志》2009年第3期164-166,178,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨绝经前后妇女血清胰岛素样生长因子-1(IGF-1)水平增高与乳腺癌发病的相关程度。方法:通过PubMed、Medline、CNKI、和维普检索1993-2007年已发表的IGF-1和乳腺癌关系的病例对照研究或队列研究文献资料,剔除不符合要求的文献,分类后应用Stata9.0软件进行一致性检验和数据合并。结果:6篇病例对照研究及5篇队列研究,共11篇文献入选;与对照组相比,未绝经妇女IGF-1的高水平与乳腺癌的发生有明显相关性,P<0.01,合并OR值为1.57,95%CI(1.26～1.95);而在绝经后妇女中,高水平的IGF-1与乳腺癌发生没有明显相关性,P=0.384,合并OR值为1.11,95%CI(0.88～1.39)。结论:对绝经前的人群检测血清IGF-1水平有助于筛选和确定乳腺癌高危患者,有利于早期诊断及判断预后。OBJECTIVE： To evaluate the association between the level of insulin-like growth factor 1 and the risk of breast cancer in women with different menopausal status. METHODS： Studies from 1993 to 2007 were searched through Medline, Pubmed, CNKI and VIP databases with case-control or cohort studies limitation and the meta-analysis with Stata9.0 was performed after categorized. RESULTS： 11 articles were selected, include 6 case-control studies and 5 cohort studies. In the premenopausal patients with malignant breast tumor, the risk of high IGF-1 level were significantly higher than those of the healthy control group （P 〈 0.01 ）, pooled odds ratio was 1.57, 95%CI（1. 26--1. 95）; but high IGF -1 level was not associated with the postmenopausal patients （P = 0. 384）, pooled odds ratio was 1.11, 95%CI （0.88-1.39）. CONCLUSION： High-risk patients for the breast cancer can be screened with the concentration of IGF -1, which is useful to early stage diagnosis and judgement of their prognosis.

关 键 词：乳腺肿瘤 胰岛素样生长因子-1 META分析 

分 类 号：R737.9[医药卫生—肿瘤]