自体淋巴结-脂肪组织移植的动物实验研究  

Experimental study of autologous lymph node-adipose tissue transplantation

作　　者：柴凡[1] 梁燕[1] 姜军[1] 

机构地区：[1]第三军医大学西南医院乳腺疾病中心,重庆400038

出　　处：《中华肿瘤防治杂志》2009年第3期171-174,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨使用显微外科技术进行自体带血管淋巴结-脂肪组织移植的可行性。方法:18只日本大耳白兔,全麻下采集自体腹股沟区浅层带血管淋巴结-脂肪组织移植于同侧前肢腋窝,利用显微外科技术吻合移植物血管,术后24周连续观察移植物存活情况,比较肢体体积变化。结果:术后16只动物上肢的移植物可以长期稳定存活并具有相应生理功能,供区采集淋巴结-脂肪组织后未诱发下肢慢性淋巴水肿,双下肢体积变化无明显统计学差异,t=1.000,P=0.333。结论:自体淋巴结-脂肪组织移植技术安全、简便、可行,动物实验为该技术向临床应用过渡提供了参考。OBJECTIVE：To investigate the feasibility of autologous lymph node-adipose tissue transplantation by microsurgery. METHODS： Eighteen Japanese White Rabbits transplanted the collected lymph node-adipose tissue from groin area with supply blood vessels to homonymy axillary fossa and rebuilt the blood supply by mierosurgery, and observed for 24 weeks after the operation. RESULTS： Autologous lymph node-adipose tissue transplantation was performed successfully in 16 rabbits. For a long time the transplanted tissue stabilized survived, the donor area have no sign of chronic lymphedema （t= 1. 000, P=0. 333）. CONCLUSION： Autologous lymph node-adipose tissue transplantation is safe, feasible and convenient, and the experiment has made a good preparation for the future clinical trials.

关 键 词：淋巴结/移植 移植 自体 显微外科手术 

分 类 号：R737.9[医药卫生—肿瘤]