一种植物生长激素-N'-(5-硝基-2-羟基苯亚甲基)-3,5-二羟基苯甲酰肼的合成、晶体结构和抗菌活性(英文)  

A Plant Growth Hormone-Synthesis, Crystal Structure and Antibacterial Activities of N'-(5-nitro-2-hydroxybenzylidene)-3, 5-dihydroxybenzohydrazide

作　　者：张娅南[1] 黄珊珊[2] 周琴[2] 潘韬文[2] 王明东 刁云鹏[2,3,4] 

机构地区：[1]大连市中心医院药剂科,辽宁大连116033 [2]大连医科大学药学院,辽宁大连116044 [3]辽宁省食品药品监督管理局技术审评中心,辽宁沈阳110032 [4]辽宁中医药大学药学院,辽宁大连116001

出　　处：《现代生物医学进展》2009年第8期1526-1528,共3页Progress in Modern Biomedicine

基　　金：supported by the Science and Technology of Dalian (Studies on the Synthesis,Characterization and Bioactivities of the Taurine Schiff base Complexes (No. 2008E11SF168)~~

摘　　要：目的:合成并表征一种属于植物生长激素的席夫碱类化合物。方法:由5-硝基水杨醛和3,5-二羟基苯甲酰肼在甲醇溶液中反应得到N'(-5-硝基-2-羟基苯亚甲基)-3,5-二羟基苯甲酰肼。结果:用单晶X-射线衍射法测得其结构并表征,同时通过抗菌实验证明其在一定浓度下具有明显的抗菌活性。结论:这种席夫碱类化合物在某种程度上具有明显的抗菌活性。Objective： A plant growth hormone, known as Schiff base compound, has been synthesized and characterized. Methotis： N＇- （5-nitro-2-hydroxybenzylidene）-3, 5-dihydroxybenzohydrazide, has been prepared by the reaction of 5-nitrosalicylaldehyde and 3,5-dihydroxybenzohydrazide in methanol solution. Results： The structure of the compound has been characterized by single-crystal X-ray diffraction, and it has moderately antibacterial activity when the concentration has been increased. Conclusions： The compound has possessed antibacterial activity to some extent.

关 键 词：席夫碱 晶体结构 抗菌活性 N’-(5-硝基-2-羟基苯亚甲基)-3 5-二羟基苯甲酰肼 

分 类 号：R914.5[医药卫生—药物化学]