肿瘤MDR1基因表观遗传调控及其对宫颈癌的启示  

Epigenetic Regulation of Multidrug Resistance Gene 1 and its Effect on Cervical Cancer

作　　者：高丽敏[1] 王英红[1] 

机构地区：[1]石河子大学第一附属医院妇产科,新疆石河子832002

出　　处：《现代生物医学进展》2009年第8期1588-1590,1600,共4页Progress in Modern Biomedicine

摘　　要：多药耐药是肿瘤细胞化疗失败的重要原因,多药耐药基因1过度表达P-gP是产生耐药的主要机制,表观遗传通过对DNA的甲基化和组蛋白脱乙酰化的修饰来调节MDR1基因的转录。应用化学物质可以逆转MDR1基因的过度表达,提高化疗敏感性,这将为癌症治疗提供新策略,也为宫颈癌的治疗提供新思路。The important reason of chemotherapy failure is that multidrug resistance gene MDR1 of cervical cancer tumor cell overexpressed P-glycoprotein, which causing multidrug resistance. The transcription of MDR1 gene can be regulated through the DNA methylation and histone modification. Using chemical factors to intervene in the epigenetic modification can reverse the MDR1 gene overexpression, and improve the sensitivity of chemotherapy. It provides a novel strategy for treatment of cervical cancer as well as other malignant tumors.

关 键 词：多药耐药基因1(MDR1) 表观遗传修饰 子宫颈癌 

分 类 号：R730.53[医药卫生—肿瘤]