人乳头状瘤病毒负荷量检测在宫颈病变诊断中的临床意义  

Clinical significance of human papillomavirus load detection in diagnosis of precancerous cervical diseases

作　　者：李萍[1] 温凯辉[1] 徐滨[2] 付玉荣[2] 刘爱军[3] 

机构地区：[1]北京军区总医院妇产科,北京100700 [2]解放军总医院妇产科,北京100853 [3]解放军总医院病理科,北京100853

出　　处：《诊断病理学杂志》2009年第2期127-128,共2页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨人乳头状瘤病毒（HPV）检测在宫颈病变诊断中的临床意义以及HPV负荷量与宫颈病变组织病理学改变的相关性。方法对解放军总医院妇科门诊2350名患者行宫颈TCT和高危型FIPV检测，并对TCT异常患者行阴道镜下宫颈组织病理学检查。结果将PHV负荷量由低至高行数量分级后，病理结果异常率分别为10．11％、31．75％、41．38％、53．02％和54．23％。结论宫颈病变发生率及严重程度与病毒负荷量密切相关，随着病毒负荷量增加，宫颈病变发生率增加，其病变程度也相应加重。Objective To investigate the clinical significance of precancerous cervical diseases with the detection of humanpapilloma virus DNA hybrid capture Ⅱ （HC Ⅱ ）, and to determine the association between viral load of HPV and stage of cervical intraepithelial neoplasia （CIN） lesion. Methods Cervical exfoliate cells from 2 350 women were collected to detect HCⅡ and TCT. Women with abnormal results of TCT were examined by eolposcepy and biopsy. Results According to the classification of HPV viral load from low quantity to high, the rate of abnormal pathologic results was 10.11%, 31.75%, 41.38%, 53.02% and 54.23% in tum. Conclusion Incidence of cervical lesions and their severity are closely associated with HPV load. With increase fo the load, incidence of cervical lesions and the severity are enhanced.

关 键 词：HPV 宫颈癌前病变 病毒负荷量 病理 

分 类 号：R737.33[医药卫生—肿瘤]