脂肪肝与HBV感染、高脂血症及ALT异常的相关分析  

Relationship of fatty liver with HBV infection, hyperlipidemia and abnormal alanine aminotransferase

作　　者：徐启桓[1] 揭育胜[1] 舒欣[1] 陈禄彪[1] 曹红[1] 李刚[1] 

机构地区：[1]中山大学附属第三医院感染科,广州510630

出　　处：《中华实验和临床病毒学杂志》2009年第2期141-143,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的了解广州市体检人群脂肪肝的患病率，探讨脂肪肝与HBV感染、高脂血症及ALT异常的关系。方法回顾性对在中山大学附属第三医院健康体检的4365名人员的临床资料进行分析。结果4365名体检者中，共检出脂肪肝793例，脂肪肝患病率18．2％。脂肪肝组，男性440例，患病率19．2％，女性353例，患病率17．1％，男女患病率差别无统计学意义（P=0．07）。乙型肝炎病毒感染人群的脂肪肝患病率为16．7％，低于非感染人群的18。3％，两者差异无统计学意义，P=0．45。高脂血症组的脂肪肝患病率为42．1％，显著高于血脂正常组的11．6％，P〈0．05。脂肪肝组的ALT异常率为32．5％，显著高于非脂肪肝组的8．6％，P〈0．05。结论广州地区人群中男女的脂肪肝患病率无显著差异。脂肪肝与乙型肝炎病毒感染无关，但与年龄、高脂血症密切相关，容易引起ALT升高。Objective To investigate the prevalence of fatty liver in Guangzhou and its relation to hepatitis B virus（ HBV）infection, hyperlipidemia and abnormal alanine aminotransferase （ALT）. Methods A retrospective analysis was made on clinical data of 4365 participants who received health check-up in our hospital. Results The prevalence of fatty liver was 18.2%, 19.2% in males and 17.1% in females, respectively. There was no significant difference between males and females（ P = 0.07）. Among 793 subjects with fatty liver, 440 were males and 353 were females. The prevalence of fatty liver was 16.7% in HBV infection group and 18.3% in the group without HBV infection, no significant difference was seen between these two groups （ P = 0.45）. The prevalence of fatty liver was 42.1% in hyperlipidemia group, and 11.6% in the group with normal serum triglyceride （TG）and total cholesterol （TC）, respectively, there was a significant difference between these two groups（ P 〈 0.05）. The abnormal ALT was seen in 32.5 % of the fattty liver group, which was significantly higher than that （8.6 % ） in the group without fatty liver （ P 〈 0.05 ）. Conclusions The prevalence of fatty liver was not significantly different between males and females in Guangzhou. Fatty liver was not related with HBV infection but closely related with age and hyperlipidemia. Fatty liver was a common cause of abnormal ALT.

关 键 词：卫生状况指标 脂肪肝 患病率 高脂血症 肝炎病毒 乙型 

分 类 号：R575.5[医药卫生—消化系统] R512.62[医药卫生—内科学]