高强度运动及心理应激对大鼠胃排空及胃肠激素的影响  

Effects of high-intensity exercises and psychological stress on gastric emptying and gastrointestinal hormones in rats

作　　者：徐伟[1] 孙维峰[1] 孙桂华[1] 梁静[1] 张娴娴[1] 刘玲[1] 李丽[1] 

机构地区：[1]广州军区广州总医院中医科,广州510010

出　　处：《解放军医学杂志》2009年第5期575-576,590,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军中药新药研究重点资助项目(NO99083)

摘　　要：目的探讨高强度运动及心理应激对大鼠胃排空及胃泌素(GAS)、胃动素(MOT)的影响。方法40只Wistar大鼠随机均分为空白对照组,低、高强度运动组,心理应激组,高强度运动+心理应激组。测定大鼠在不同强度运动及心理应激后的胃排空率及GAS、MOT含量。结果与空白对照组比较,低强度运动组大鼠的体重、胃排空率、GAS无明显变化(P>0.05),但MOT升高(P<0.05);高强度运动组及心理应激组大鼠的体重、胃排空率、GAS、MOT均明显下降(P<0.01或P<0.05);与高强度运动组比较,心理应激组及高强度运动+心理应激组大鼠胃排空率、GAS、MOT下降更明显(P<0.01或P<0.05);高强度运动+心理应激组与心理应激组比较无显著差异(P>0.05)。结论高强度运动可引起实验大鼠胃排空率、GAS、MOT水平下降,而心理应激对胃排空率、GAS、MOT的影响更大,共同作用比单一因素的影响更显著。Objective To study the effects of high intensity exercises and psychological stress on gastric emptying and the secretion of gastrointestinal hormones motilin （MOT） and gastrin （GAS） in rats. Methods Forty Wistar rats were divided into 5 groups （8 each） ： control group, low-intensity exercise group, high-intensity exercise group, psychological stress group, and high-intensity exercise plus psychological stress group. Gastric emptying ratios, GAS and MOT contents were measured after exercises of different intensity and psy chological stress. Results Compared with the control group, the body weight, gastric emptying ratio and GAS content showed no difference （P〉0.05）, while MOT increased （P〈0.05） in low-intensity exercise group; the body weight, gastric emptying ratio, GAS and MOT contents were significantly decreased （P〈0. 01 or P〈0. 05） both in high-intensity exercise group and psychological stress group. Compared with the high-intensity exercise group, the gastric emptying ratio and the GAS and MOT contents were decreased significantly （ P〈0.01 or P〈0. 05） both in psychological stress group and high-intensity exercise plus psychological stress group. While no significant difference was found in these items between high-intensity exercise plus psychological stress group and psychological stress group. Conclusions High-intensity exercise can decrease the gastric emptying rate and the GAS and MOT eontents. Psychological stress may throw a great influence on the gastric emptying and GAS and MOT contents.

关 键 词：应激 胃排空 胃泌素类 促胃动素 

分 类 号：R573.9[医药卫生—消化系统]