JAK/STAT信号通路及其与肿瘤侵袭、转移的关系  

JAK/STAT signaling pathway and its relationship with tumor invasion and metastasis

作　　者：吴剑锋[1] 沈佐君[1] 

机构地区：[1]安徽医科大学附属省立医院,安徽省立医院,安徽省临检中心,合肥230001

出　　处：《生命的化学》2009年第2期176-179,共4页Chemistry of Life

摘　　要：Janus蛋白酪氨酸激酶(Janus protein tyrosine kinase,JAK)是近几年来鉴定出来的在细胞信号转导过程中起重要作用的非受体型蛋白酪氨酸激酶。JAK和信号转导和转录活化蛋白(signal transducer and activator of transcription,STAT)在多种肿瘤中表达或高表达。本文就JAK/STAT信号通路及其在肿瘤的侵袭和转移中的作用作一概述,为肿瘤的靶向治疗提供新思路。Janus protein tyrosine kinase OAK）, which has been identified in recent years, plays an important role in the signal transduction in the non-receptor protein-tyrosine kinase. Both JAKs and STATs （signal transducer and activator of transcription） are expressed or highly expressed in a variety of tumors. This paper summarized the role of the JAK/STAT signaling pathway in the invasion and metastasis of tumor, which provides new targeted therapy ideas for tumors.

关 键 词：JAK STAT 信号转导 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]