HAMLET的生物学特性及其在肿瘤治疗中的作用  

Biological features of HAMLET and its roles in tumor treatment

作　　者：夏嘉志[1] 陈汉春[1] 

机构地区：[1]中南大学生物科学与技术学院生物化学系,长沙410013

出　　处：《生命的化学》2009年第2期189-191,共3页Chemistry of Life

基　　金：国家自然科学基金(30371660);中华医学基金会基金(CMB99-698)资助

摘　　要：HAMLET是部分折叠的人α-乳清蛋白与油酸形成的复合物,它可侵入肿瘤细胞并致线粒体膜去极化、释放细胞色素c,进而入核与组蛋白结合并抑制基因转录,使细胞核凝结而最终使肿瘤细胞凋亡。HAMLET的临床应用研究拓展了肿瘤治疗的新策略。HAMLET （human alpha-lactalbumin made lethal to tumor cells） is a complex molecule which consists of partially unfolded human alpha-lactalbumin and oleic acid. HAMLET invades tumor cells and causes mitochondrial membrane depolarization, cytochrome c release, and is then transferred into nuclei. In nuclear of the attacked cancer cell, HAMLET interacts with histones and inhibits gene transcription, and finally induces tumor cell apoptosis through nuclear condensation. The application study of HAMLET has been developing new strategies of clinical treatment for tumors.

关 键 词：HAMLET 肿瘤治疗 细胞凋亡 

分 类 号：R730.5[医药卫生—肿瘤]