微RNA在肝癌中的作用及其应用前景  

The roles and clinical applications of microRNAs in hepatocellular carcinoma

作　　者：丁洁[1] 黄胜林[1] 梁琳慧[1] 屠红[1] 何祥火[1] 

机构地区：[1]上海交通大学医学院,上海市肿瘤研究所癌基因及相关基因国家重点实验室,上海200032

出　　处：《生命的化学》2009年第2期243-246,共4页Chemistry of Life

基　　金：上海市科委"创新行动计划"重大基础研究项目(07DJ14006);人事部留学人员科技活动择优资助基金(2007-170)资助

摘　　要：微RNA(microRNA,miRNA)是一类长度为21～25个核苷酸的非编码小分子RNA,广泛存在于各种真核生物中。miRNA主要通过促进靶mRNA的降解或抑制其翻译过程而发挥负调控作用。越来越多的证据表明,miRNA起着调控基因表达的重要作用,miRNA的变异与疾病,尤其是恶性肿瘤的发生发展存在密切的关系。本文就miRNA与肝癌的发生发展、诊断、预防、预测及治疗等相关研究作一综述。MicroRNAs （miRNAs） are 21-25 nucleotides, small non-coding RNA molecules expressed in a variety of eukaryotes, which are highly conserved across mammals, worms and flies, miRNAs regulate gene expression at the post-transcriptional level through degradation or translational repression of their target mRNAs. Recent findings suggested that miRNAs play crucial roles in cell proliferation, cell death, metabolism and development, etc. Moreover, their dysregulations could be involved in the development of diseases, particularly human malignancies. This review focused on the roles of miRNAs in the development of hepatocellular carcinoma, and their potential applications in diagnostic and prognostic prediction and treatment of liver cancer.

关 键 词：微RNA 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]