乙肝肝硬化患者血清铁蛋白、转铁蛋白水平检测及意义  

Clinical Significance of Serum Ferritin and Transferrin Assay in Patients with Liver Cirrhosis

作　　者：张宏[1] 李强[1] 李友生[1] 张志涛[1] 李淑敏[1] 申广文 张贵利[1] 李英欣[1] 

机构地区：[1]河北省邯郸市传染病医院检验科,河北邯郸056002

出　　处：《标记免疫分析与临床》2009年第2期75-76,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨乙肝肝硬化患者血清铁蛋白(FE)和转铁蛋白(TF)的变化,选择68例乙肝肝硬化患者,用放射免疫法检测FE,ELISA法检测TF。结果表明,Child-Pugh各级肝硬化患者FE水平均高于对照组,并依Child-pugh A、B、C分级上升;TF水平均低于对照组,并依Child-Pugh分级下降。提示FE和TF水平一定程度可以反映乙肝肝硬化患者的病变严重程度,过重的铁负荷可能协助乙肝病毒加重肝细胞损伤。To investigate the clinical significance of serum ferritin （ FE ） and transferrin （TF） in patients with liver cirrhosis. The serum ferritin and transferrin levels in 68 patients with liver cirrhosis were detected by RIA and by ELISA respectively. The results showed that the FE levels in patients with liver cirrhosis were significantly higher than that of in control group and turned to increase with the rank of Child-Pugh A , B and C. The TF levels in patients were significantly lower than that of in control group and turned to decrease with the rank of Child-Pugh. The FE and TF levels could he regarded as a reference index in forecasting the degree of liver cirrhosis state. The overload of iron may enhance the hepatocyte damage induced by HBV.

关 键 词：肝硬化 铁蛋白 转铁蛋白 放射免疫法 ELISA 

分 类 号：R575.2[医药卫生—消化系统]