不同雌激素受体状态乳腺癌患者血清有机氯农药残留物水平研究  

Study on the serum organochlorine pesticides residues levels in breast cancer patients with different estrogen receptor

作　　者：李明[1] 孙东良[3] 李瑞伟[1] 徐卫国[1] 付桂茹[2] 刘淑兰[2] 

机构地区：[1]华北煤炭医学院附属医院肿瘤外科,唐山063000 [2]华北煤炭医学院附属医院泌尿外科,唐山063000 [3]河北省唐海县医院普通外科

出　　处：《中国综合临床》2009年第5期534-537,共4页Clinical Medicine of China

摘　　要：目的研究不同雌激素受体状态乳腺癌患者血清有机氯农药残留物水平。方法收集唐山市丰南区乳腺癌患者93例、唐海县65例，均经病理证实其雌激素受体状态，并采用附ECD检测器的气相色谱仪检测其血清中有机氯农药（DDTs和HCHs）含量并比较其差异。结果两地区乳腺癌患者血清中HCH各异构体检出率顺序为B—HCH〉8-HCH〉α-HCH〉γ-HCH，血清DDT各异构体检出率顺序为PP＇-DDE〉PP＇-DDT〉OP’-DDT〉PP＇-DDD。乳腺癌患者血清中β-HCH、PP’-DDE含量与年龄及BMI呈正相关（年龄：r值分别为0．272、0．330，P均〈0．01；BMI：r值分别为0．312、0．187，P值分别为〈0．01、〈0．05）。雌激素受体阳性患者与雌激素受体阴性患者血清β—HCH、δ-HCH、PP’-DDE含量差异均有统计学意义（P均〈0．05）。结论雌激素受体阳性乳腺癌患者血清有机氯农药残留物含量高于雌激素受体阴性患者，结果提示乳腺癌是激素依赖性肿瘤，发病受激素状态的影响，其发病可能与血清有机氯农药残留物的拟雌激素作用有关。Objective To evaluate the serum organochlorine pesticides residues levels in breast cancer patients with different estrogen receptor（ER）. Methods 93 patients of breast cancer from Fengnan districtand 65 patients from Tanghai county in Tangshan were selected,whose ER were detected by pathology and serum organochlorine pesticides （DDTs and HCHs） levels were detected and compared with gas chromatography/electron capture.Results The orders of detection rate of HCH isomer in breast cancer patients in two areas were β-HCH 〉 δ- HCH 〉 α-HCH 〉 γ-HCH. The orders of detection rate of DDT isomer in breast cancer patients in two areas were PP＇- DDE 〉 PP＇-DDT 〉 OP＇-DDT 〉 PP＇-DDD. The serum levels of β-HCH,PP＇-DDE in breast cancer patients in two areas were positively correlated with age （ r = 0. 272 ,0. 330 ,P 〈 0.01 ） or BMI （ r = 0.312,0. 187,P 〈 0.01, 〈 0.05 ）. There were statistical differences in the serum β-HCH,δ-HCH,PP＇-DDE levels between the estrogen receptor positive breast cancer patients and the estrogen receptor negative breast cancer patients in two areas （ P 〈 0. 05 for each）. Conclusion The serum organochlorine pesticides residues levels in breast cancer patients with positive estrogen receptor are higher than that with negative estrogen receptor,implicating that breast cancer is dependent on estrogen. The cause of breast cancer is likely due to estrogen-like effect of serum organochlorine pesticides residues.

关 键 词：乳腺癌 雌激素受体 六六六 滴滴涕 

分 类 号：R737.9[医药卫生—肿瘤] R284.1[医药卫生—临床医学]