N-硝基-N,N′-二苯基脲衍生物的合成及抑菌活性  

Synthesis and Bacteriostatic Activity of N-nitro-N,N′-diphenyl Urea Derivatives

作　　者：许洪涛[1] 申晓霞[1] 曹丹[1] 陈长水[1] 

机构地区：[1]华中农业大学化学系,武汉430070

出　　处：《应用化学》2009年第5期507-510,共4页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(39770845)

摘　　要：采用“一锅法”设计合成了9个N-硝基脲衍生物，收率50．2％～76．8％。通过红外光谱、核磁共振氢谱及元素分析等测试技术确证了它们的结构。初步抑菌活性测试表明，当质量浓度为50mg／L时，各化合物对所测试菌种均表现出不同程度的抑菌活性。其中，化合物3d和3e对水稻纹枯菌的抑菌率超过50％。量化计算结果表明，分子中的脲桥是该类化合物的抑菌活性部位。Nine compounds of N-nitro urea were prepared by one pot method. The yields of products were in a range of 50. 2% - 76.8%. The structures of the compounds were identified by ^1H NMR, IR and elemental analysis. Preliminary bacteriostatic activity tests show that all the compounds exhibited varying degrees of anti- bacterial activity on tested strains when the concentration was 50 mg/L; especially, the inhibitory rates of compounds 3d and 3e on Rhizoctonia Solani were over 50%. Quantum chemistry calculation resuhs indicate that the urea-bridge in the compounds was the chemical active site for such bacteriostatic activity.

关 键 词：N-硝基脲 合成 抑菌活性 量子化学计算 

分 类 号：O625.6[理学—有机化学]