河南地区食管鳞癌和贲门腺癌与人乳头瘤病毒感染相关性的分析  

Correlation between human papillomavirus infection and esophageal squamous cell carcinoma and gastric cardia adenocarcinoma in high-incidence area of Henan province

作　　者：丁广成[1] 王立东[1] 李韶华[1] 冯常炜[2] 张延瑞[3] 任景丽[4] 范宗民[1] 王苒[1] 何欣[1] 郭涛[1] 

机构地区：[1]河南省食管癌重点开放实验室郑州大学第一附属医院郑州大学基础医学院,河南郑州450052 [2]郑州大学第二附属医院消化内科,河南郑州450014 [3]河南省人民医院消化内科,河南郑州450003 [4]郑州大学第二附属医院病理科,河南郑州450014

出　　处：《中华肿瘤防治杂志》2009年第4期252-255,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：河南省自然科学基金(0511043200);河南省医学科技重大攻关项目(WKJ2007-2-028)

摘　　要：目的:了解人乳头瘤病毒16型(HPV16)与河南食管癌高发地区食管鳞癌、贲门腺癌发生的关系。方法:利用聚合酶链式反应(PCR)对高发区食管鳞癌组织(44例)、贲门腺癌组织(18例)进行HPV-DNA检测。结果:食管鳞癌及贲门腺癌组织中均检测到HPV16 E6 DNA表达,但食管鳞癌HPV16 E6 DNA表达(84%,37/44)明显高于贲门腺癌(44%,8/18),P<0.01。食管鳞癌及贲门腺癌组织中,高危型HPV16 E6 DNA表达与患者年龄、性别、分化程度、浸润程度、淋巴结转移以及肿瘤分级无相关性,P值均>0.05。结论:同一地区食管鳞癌和贲门腺癌均有不同程度HPV感染,提示HPV可能是两者共同相关致病危险因素,高危型HPV16感染可能在食管鳞癌和贲门腺癌发生中起重要作用。OBJECTIVE： To investigate the relationship between human papillomavirus （HPV） infection and the development of esophageal squamous cell carcinoma （SCC） and gastric cardia adenocarcinoma（GCA） in the high risk area for esophageal cancer in Henan. METHODS： HPV DNA was detected by polymerase chain reaction （PCR） in 44 surgically resected specimens of SCC, and 18 specimens of GCA. RESULTS： The positive rates of HPV16 E6 DNA were 84 % （37/44） in SCC and 44% （8/18） in GCA, respectively. There was a significant difference between SCC and GCA, P〈0.01. However, there was no correlation between HPV16 DNA and the gender, age, tumor size, depth of penetration, differentiation, lymph node metastasis and TNM stages of SCC and GCA, all P〉0.05. CONCLUSIONS： The consistent HPV infection in SCC and GCA from the patients at the same area suggests that HPV may be one of the common oncogenic factors for both SCC and GCA. HPV16, the high-risk type, may play an im- portant role in the development of SCC and GCA.

关 键 词：癌 鳞状细胞 食管肿瘤 胃肿瘤 腺癌 贲门 乳头状瘤病毒 人 

分 类 号：R735[医药卫生—肿瘤]