乳腺癌组织COX-2和Bcl-2蛋白表达及其临床意义  

Expressions and significance of COX-2 and Bcl-2 in breast cancer tissues

作　　者：杨晓文[1] 崔明[1] 王世清[1] 莫平[1] 

机构地区：[1]成都军区昆明总医院普外科,云南昆明650032

出　　处：《中华肿瘤防治杂志》2009年第4期295-298,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨乳腺癌组织COX-2和Bcl-2蛋白的表达及其意义。方法:选取102例乳腺癌组织为研究对象,各对应的癌旁组织为对照组,并选取30例正常乳腺组织为正常对照组。采用免疫组化ABC法检测各样本的COX-2和Bcl-2蛋白表达,并对所得数据进行统计分析。结果:COX-2及Bcl-2蛋白在乳腺癌组织中的阳性表达均明显高于癌旁组织及正常对照组织,P=0.000。Ⅲ、Ⅳ期患者以及淋巴结转移阳性组COX-2的阳性表达分别高于Ⅰ、Ⅱ期患者和淋巴结转移阴性组,P值分别为0.014和0.001;COX-2表达与患者年龄(P=0.866)、肿瘤大小(P=0.286)及组织学类型(P=0.148)均无相关性。淋巴结转移阳性组Bcl-2的阳性表达明显高于淋巴结转移阴性组,P=0.000;Bcl-2表达与患者年龄(P=0.260)、肿瘤大小(P=0.060)、组织学类型(P=0.170)及TNM分期(P=0.452)均无相关性。乳腺癌组织中COX-2与Bcl-2表达显著正相关,r=0.659,P=0.01。结论:COX-2与Bcl-2在乳腺癌组织中均高度表达且密切相关,两者可能共同促进乳腺癌的发生、发展。OBJECTIVE： To explore the expressions and significance of cycloxygenase-2 （COX-2） and B-cell lymphoma/leuke-2 （Bcl-2） in breast cancer tissues. METHODS： A total of 102 cases of breast cancer were selected as a study group,and the relative noncarcinoma tissues were selected as a control group,and 30 cases of normal breast tissues were selected as a normal control group. Immunohistochemical method （ABC） was used to test the COX-2 and Bcl-2 protein. The data was statistically analyzed. RESULTS： The positive expression rates of COX-2 and Bcl-2 protein in breast cancer tissues were higher than those in noncarcinoma tissues and normal tissues （P= 0. 000）. The positive expression rates of COX-2 in the stage Ⅲ and Ⅳ and the patients with lymphaden metastasis were higher than those in the stage Ⅰ and Ⅱ and the patients without lymphaden metastasis （P=0. 014 and P=0. 001 respectively）, while there was no significantly difference in the age （P=0. 866）, tumor size （P=0. 286） and histological type （P=0. 148）. The positive expression rates of Bcl-2 of the patients with lymphaden metastasis were higher than those of the patients without lymphaden metastasis （P=0. 000）, while there was no significantly differences in the age （P = 0. 260）, tumor size （P= 0. 060）, histological type （P = 0. 170） and tumor, nodes, metastasisclassification （TNM） （P=0. 452）. In correlation analysis,there was a significant positive correlation between COX-2 and Bcl-2 in breast cancer（r = 0. 659, P = 0.01）. CONCLUSIONS： There are high positive expression rates of COX-2 and Bcl-2 in breast cancer tissues with significant positive correlation. The carcinogenic agents may induce the overexpression of COX-2, which may promote the development of breast cancer.

关 键 词：乳腺肿瘤/病理学 氧合酶类 原癌基因蛋白质C-BCL-2 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]